HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: AP2M1 (Q96CW1)
AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein)
Gene: AP2M1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.643

Property	Details
Experiments	35063084, 26269332, 32357304
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 435
+	Hs
		497548 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AP1M1_HUMAN (2-434): 5.69e-170: 484: 38.85
+	Rn
		581982 TAU_RAT (1-758): 4.86e-75: 260: 71.47		AP2M1_RAT (1-435): 1.03e-178: 507: 100.00
+	Rn
		94205 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		AP2M1_RAT (1-435): 1.03e-178: 507: 100.00
+	Mm
		498008 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		AP2M1_MOUSE (1-435): 1.03e-178: 507: 100.00
+	Hs
		497844 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AP3M1_HUMAN (1-434): 1.4e-123: 366: 24.66
+	Hs
		496626 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AP3M2_HUMAN (1-434): 2.92e-119: 355: 24.89
+	Hs
		654028 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00
+	Hs
		203244 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00
+	Dm
		248311 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		O62530_DROME (1-435): 7.78e-171: 487: 86.56