HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: MARK4 (Q96L34)
MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1)
Gene: MARK4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	14594945, 23666762
Identification Methods	enzymatic study, fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000226 - microtubule cytoskeleton organization GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008017 - microtubule binding GO:0015630 - microtubule cytoskeleton and 2 others more... GO:0030425 - dendrite GO:0043005 - neuron projection
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 752
+	Hs
		496358 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK3_HUMAN (1-752): 0: 701: 58.56
+	Hs
		497224 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK2_HUMAN (2-752): 0: 639: 48.15
+	Hs
		497702 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK1_HUMAN (1-752): 0: 632: 51.06
+	Hs
		654032 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		MARK4_HUMAN (1-752): 0: 733: 100.00
+	Hs
		503298 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		MARK4_HUMAN (1-752): 0: 733: 100.00
+	Hs
		503266 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		MARK3_HUMAN (1-752): 0: 701: 58.56
+	Hs
		497023 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MELK_HUMAN (59-752): 1.3e-176: 522: 26.44
+	Hs
		497272 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		BRSK2_HUMAN (55-504): 2.77e-146: 447: 36.66
+	Hs
		496670 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SIK1_HUMAN (37-662): 2.63e-142: 438: 33.74
+	Hs
		497840 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SIK3_HUMAN (56-367): 1.81e-109: 363: 59.32
+	Mm
		592769 MTAP2_MOUSE (26-758): 1.71e-30: 131: 23.89		BRSK2_MOUSE (55-504): 8.46e-147: 448: 36.66