HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: SPAG5 (Q96R06)
Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126)
Gene: SPAG5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	26269332
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008017 - microtubule binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 1193
+	Hs
		654035 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		SPAG5_HUMAN (1-1193): 4.62e-140: 457: 100.00
+	Hs
		497769 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MYH2_HUMAN (192-1011): 9.96e-28: 124: 10.37
+	Hs
		254438 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ROCK2_HUMAN (526-1193): 1.76e-21: 103: 11.92
+	Hs
		496228 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DESP_HUMAN (501-1190): 6.44e-19: 95.8: 11.43
+	Hs
		497371 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MY18A_HUMAN (692-1192): 6.2e-16: 85.8: 13.78
+	Hs
		497239 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MYH14_HUMAN (449-1088): 6.07e-13: 75.8: 14.74
+	Hs
		497051 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PLEC_HUMAN (462-1139): 9.56e-12: 72: 14.40
+	Hs
		496439 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MYH10_HUMAN (837-1188): 2.71e-11: 70.7: 11.33
+	Hs
		496438 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MYH9_HUMAN (873-1192): 7.59e-11: 69.1: 13.04
+	Rn
		582036 TAU_RAT (1-758): 4.86e-75: 260: 71.47		MYH10_RAT (837-1188): 2.56e-11: 70.7: 11.33
+	Rn
		94262 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		MYH10_RAT (837-1188): 2.56e-11: 70.7: 11.33
+	Hs
		503287 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		PLEC_HUMAN (462-1139): 9.56e-12: 72: 14.40
+	Hs
		1056879 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		MYH14_HUMAN (449-1088): 6.07e-13: 75.8: 14.74
+	Hs
		148818 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		CTRO_HUMAN (356-721): 3.32e-10: 66.9: 9.51
+	Hs
		149481 PCLO_HUMAN (46-758): 3.43e-16: 85.9: 9.19		CTRO_HUMAN (356-721): 3.32e-10: 66.9: 9.51