HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: SRPK1 (Q96SB4)
SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1)
Gene: SRPK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	23197718
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane and 1 others more... GO:0016607 - nuclear speck
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 655
+	Hs
		496832 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SRPK2_HUMAN (48-655): 9.43e-136: 415: 57.97
+	Mm
		251042 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		SRPK1_MOUSE (1-655): 7.87e-152: 455: 83.16
+	Mm
		222342 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		SRPK2_MOUSE (13-655): 1.34e-129: 399: 52.49
+	Hs
		497071 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KS6A1_HUMAN (1-359): 2.84e-81: 273: 14.32
+	Hs
		496604 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KS6A3_HUMAN (1-353): 1.92e-78: 266: 13.83
+	Hs
		653958 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		SRPK2_HUMAN (48-655): 9.43e-136: 415: 57.97
+	Hs
		942660 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		SRPK2_HUMAN (48-655): 9.43e-136: 415: 57.97
+	Hs
		497376 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DYRK2_HUMAN (483-654): 8.53e-63: 220: 32.47
+	Hs
		496330 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CDK2_HUMAN (414-653): 1.01e-65: 219: 19.43
+	Hs
		496358 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK3_HUMAN (409-655): 3.06e-47: 179: 12.65
+	Hs
		497224 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK2_HUMAN (409-654): 1.03e-46: 178: 12.70
+	Hs
		497452 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK4_HUMAN (456-654): 2.51e-18: 91.4: 18.05
+	Hs
		1057021 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		KS6A6_HUMAN (1-349): 8.64e-77: 261: 15.01
+	Sp
		194038 YFHH_SCHPO (5-755): 4.88e-12: 72: 8.72		DSK1_SCHPO (54-235): 1.53e-78: 261: 50.27
+	Hs
		503266 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		MARK3_HUMAN (409-655): 3.06e-47: 179: 12.65
+	Hs
		654032 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		MARK4_HUMAN (456-654): 2.51e-18: 91.4: 18.05
+	Hs
		503298 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		MARK4_HUMAN (456-654): 2.51e-18: 91.4: 18.05