HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: M3K5 (Q99683)
Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)
Gene: MAP3K5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	26402096
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 758 Hs			1 1374
+	Hs
		496358 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK3_HUMAN (625-1374): 2.41e-158: 497: 15.81
+	Hs
		497224 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK2_HUMAN (629-1374): 9.11e-149: 472: 14.03
+	Hs
		497702 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK1_HUMAN (622-1374): 4.12e-143: 458: 15.27
+	Hs
		254438 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ROCK2_HUMAN (668-1343): 7.3e-114: 392: 17.55
+	Hs
		496604 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KS6A3_HUMAN (623-1074): 1.34e-117: 387: 19.83
+	Hs
		497071 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KS6A1_HUMAN (629-1074): 4.77e-113: 374: 18.70
+	Hs
		92372 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		E9PBG7_HUMAN (678-1086): 9.38e-113: 366: 22.73
+	Hs
		270366 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KS6A5_HUMAN (673-1088): 5.06e-109: 365: 19.51
+	Hs
		503266 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		MARK3_HUMAN (625-1374): 2.41e-158: 497: 15.81
+	Hs
		496951 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PAK2_HUMAN (686-960): 1.26e-97: 325: 31.27
+	Hs
		496977 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KCC2D_HUMAN (678-995): 1.4e-97: 324: 26.53
+	Mm
		498111 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		KCC2G_MOUSE (678-1086): 2.9e-112: 365: 22.80
+	Hs
		653939 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		NEK4_HUMAN (680-1303): 2.63e-113: 378: 19.70
+	Hs
		851493 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		NEK4_HUMAN (680-1303): 2.63e-113: 378: 19.70
+	Hs
		1057021 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		KS6A6_HUMAN (673-1074): 2.65e-113: 375: 21.31
+	Hs
		160565 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		AURKA_HUMAN (551-947): 1.43e-115: 369: 22.36
+	Mm
		592770 MTAP2_MOUSE (26-758): 1.71e-30: 131: 23.89		KCC2D_MOUSE (678-995): 1.4e-97: 324: 26.53
+	Hs
		496407 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AKT1_HUMAN (438-615): 7.18e-25: 112: 13.64
+	Hs
		496408 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AKT2_HUMAN (438-620): 9.26e-25: 111: 13.24
+	Hs
		152597 KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55		AKT1_HUMAN (438-615): 7.18e-25: 112: 13.64