HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: ROAA (Q99729)
Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (APOBEC1-binding protein 1) (ABBP-1)
Gene: HNRNPAB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26269332
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 758 Hs			1 332
+	Hs
		453100 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ROA1_HUMAN (58-235): 7.34e-71: 226: 38.38
+	Hs
		496995 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		HNRPD_HUMAN (32-332): 1.26e-55: 186: 55.63
+	Hs
		496607 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ROA3_HUMAN (36-237): 3.44e-53: 180: 36.36
+	Hs
		161944 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		HNRDL_HUMAN (12-332): 3.27e-51: 176: 49.85
+	Hs
		201653 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MSI1H_HUMAN (53-287): 4.72e-49: 169: 35.15
+	Rn
		582022 TAU_RAT (1-758): 4.86e-75: 260: 71.47		ROA3_RAT (36-237): 3.53e-53: 180: 36.36
+	Rn
		94248 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		ROA3_RAT (36-237): 3.53e-53: 180: 36.36
+	Hs
		496306 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ROA2_HUMAN (63-246): 1.97e-38: 141: 38.22
+	Rn
		64991 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		ROA2_RAT (63-246): 2.76e-38: 140: 38.22
+	Rn
		64993 TAU_RAT (1-758): 4.86e-75: 260: 71.47		ROA2_RAT (63-246): 2.76e-38: 140: 38.22
+	Hs
		496937 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ELAV2_HUMAN (127-235): 2.25e-16: 80.6: 11.82
+	Hs
		497424 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MSI2H_HUMAN (57-310): 1.5e-15: 77.9: 19.14
+	Hs
		496346 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ELAV4_HUMAN (144-235): 3.74e-15: 77.5: 13.98
+	Hs
		496957 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PABP4_HUMAN (144-238): 3.57e-11: 66: 15.63
+	Hs
		496179 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PABP1_HUMAN (144-238): 2.78e-10: 63.3: 15.63
+	Hs
		654044 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		ROAA_HUMAN (1-332): 2.58e-68: 218: 100.00
+	Hs
		1056955 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		ROAA_HUMAN (1-332): 2.58e-68: 218: 100.00
+	Rn
		582032 TAU_RAT (1-758): 4.86e-75: 260: 71.47		PABP1_RAT (144-238): 2.54e-10: 63.3: 15.63
+	Rn
		94258 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		PABP1_RAT (144-238): 2.54e-10: 63.3: 15.63
+	Mm
		498050 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		ELAV4_MOUSE (144-235): 4.15e-15: 77.2: 13.98