HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: MEP50 (Q9BQA1)
Methylosome protein WDR77 (Androgen receptor cofactor p44) (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77) (p44/Mep50)
Gene: WDR77

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35063084
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 342
+	Hs
		496503 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		LIS1_HUMAN (62-339): 9.49e-75: 238: 16.72
+	Hs
		496440 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		COPB2_HUMAN (54-331): 3.17e-47: 172: 18.38
+	Hs
		196948 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PRP4_HUMAN (253-341): 3.86e-10: 62.8: 13.40
+	Hs
		1056974 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		WDR33_HUMAN (58-331): 3.52e-67: 230: 17.86
+	Hs
		654026 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		FBXW7_HUMAN (3-236): 5.23e-43: 159: 14.29
+	Hs
		152678 KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55		FBXW7_HUMAN (3-236): 5.23e-43: 159: 14.29
+	Hs
		1281391 PRR36_HUMAN (1-607): 1.27e-15: 83.6: 10.11		FBXW7_HUMAN (3-236): 5.23e-43: 159: 14.29
+	Hs
		653951 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		WDR5_HUMAN (247-341): 5.14e-19: 88.2: 19.79
+	Dm
		248488 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		COPB2_DROME (22-239): 4.04e-34: 134: 15.70
+	Hs
		152622 KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55		WDR5_HUMAN (247-341): 5.14e-19: 88.2: 19.79
+	Hs
		152663 KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55		WDR5B_HUMAN (3-106): 2.76e-09: 59.7: 7.90
+	Dm
		1370295 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		POC1_DROME (201-335): 1.71e-23: 101: 19.12
+	Mm
		903669 KMT2C_MOUSE (228-587): 6.06e-09: 61.9: 16.84		WDR5_MOUSE (247-341): 5.14e-19: 88.2: 19.79
+	Hs
		903374 KMT2C_HUMAN (83-649): 6.28e-09: 61.8: 12.91		WDR5_HUMAN (247-341): 5.14e-19: 88.2: 19.79