HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: HNRL1 (Q9BUJ2)
Heterogeneous nuclear ribonucleoprotein U-like protein 1 (Adenovirus early region 1B-associated protein 5) (E1B-55 kDa-associated protein 5) (E1B-AP5)
Gene: HNRNPUL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	26269332, 35063084
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0019899 - enzyme binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 856
+	Hs
		496863 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		HNRPU_HUMAN (1-701): 0: 662: 40.41
+	Mm
		498103 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		HNRPU_MOUSE (1-701): 0: 664: 41.47
+	Hs
		497122 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		HNRL2_HUMAN (1-707): 0: 587: 38.67
+	Mm
		498013 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		HNRL2_MOUSE (1-707): 0: 600: 38.93
+	Hs
		1056849 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		HNRL2_HUMAN (1-707): 0: 587: 38.67
+	Hs
		497359 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DDX1_HUMAN (141-512): 9.29e-85: 288: 21.91
+	Hs
		497470 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RANB9_HUMAN (142-503): 1.14e-67: 241: 18.90
+	Dm
		1097991 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		RYR_DROME (117-679): 1.09e-86: 305: 15.01
+	Hs
		654038 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		RANB9_HUMAN (142-503): 1.14e-67: 241: 18.90
+	Hs
		1057010 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		ASH2L_HUMAN (25-410): 6.7e-69: 242: 16.20
+	Hs
		152695 KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55		ASH2L_HUMAN (25-410): 6.7e-69: 242: 16.20
+	Hs
		1170094 SRCAP_HUMAN (2-474): 1.09e-12: 74.3: 9.83		ASH2L_HUMAN (25-410): 6.7e-69: 242: 16.20
+	Mm
		1207211 KMT2C_MOUSE (228-587): 6.06e-09: 61.9: 16.84		ASH2L_MOUSE (25-410): 6.82e-70: 244: 16.44
+	Hs
		1243848 KMT2C_HUMAN (83-649): 6.28e-09: 61.8: 12.91		ASH2L_HUMAN (25-410): 6.7e-69: 242: 16.20
+	Hs
		1140678 PRG4_HUMAN (4-604): 5.21e-20: 97.8: 8.93		RN123_HUMAN (243-412): 6.53e-44: 174: 26.86
+	Hs
		1140884 PCLO_HUMAN (46-758): 3.43e-16: 85.9: 9.19		RN123_HUMAN (243-412): 6.53e-44: 174: 26.86
+	Hs
		1140633 KMT2C_HUMAN (83-649): 6.28e-09: 61.8: 12.91		RN123_HUMAN (243-412): 6.53e-44: 174: 26.86