HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: SRBS1 (Q9BX66)
Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)
Gene: SORBS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane and 1 others more... GO:0045121 - membrane raft
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 1292
+	Hs
		203250 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		SRBS1_HUMAN (1-1292): 5.5e-176: 558: 100.00
+	Hs
		496988 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SPTN1_HUMAN (304-902): 8.17e-59: 225: 13.39
+	Rn
		555250 TAU_RAT (1-758): 4.86e-75: 260: 71.47		SPTN1_RAT (304-921): 4.41e-58: 223: 13.62
+	Rn
		94140 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		SPTN1_RAT (304-921): 4.41e-58: 223: 13.62
+	Hs
		497012 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SRC8_HUMAN (991-1288): 1.92e-23: 108: 13.38
+	Rn
		582013 TAU_RAT (1-758): 4.86e-75: 260: 71.47		SRC8_RAT (993-1288): 3.14e-20: 97.9: 14.72
+	Rn
		94238 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		SRC8_RAT (993-1288): 3.14e-20: 97.9: 14.72
+	Hs
		557613 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		NCK1_HUMAN (708-1005): 1.37e-49: 182: 18.27
+	Hs
		203208 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		NCK1_HUMAN (708-1005): 1.37e-49: 182: 18.27
+	Dm
		113976 M9PB30_DROME (69-755): 2.38e-24: 112: 8.39		M9PB30_DROME (21-776): 2.85e-13: 77.4: 10.64
+	Hs
		203224 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		MYO1E_HUMAN (1089-1290): 2.99e-25: 116: 16.06
+	Rn
		192744 SYNJ1_RAT (72-557): 4.95e-13: 75: 12.10		SRBS2_RAT (508-926): 5.66e-14: 79.4: 15.40
+	Rn
		193638 SYNJ1_RAT (72-557): 4.95e-13: 75: 12.10		SH3G1_RAT (780-926): 2.11e-14: 78.4: 26.14
+	Hs
		203228 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		ITSN1_HUMAN (273-858): 7.03e-15: 82.5: 10.91
+	Hs
		203192 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		SRBS2_HUMAN (516-926): 8.23e-14: 78.7: 14.74
+	Hs
		203230 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		SH319_HUMAN (793-851): 9.71e-11: 68.4: 37.29
+	Hs
		203191 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		VINEX_HUMAN (852-938): 9.3e-09: 61.9: 27.59