HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: PACN1 (Q9BY11)
Protein kinase C and casein kinase substrate in neurons protein 1 (Syndapin-1)
Gene: PACSIN1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.573

Property	Details
Experiments	23035120
Identification Methods	affinity chromatography technology, two hybrid, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 444
+	Hs
		497800 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PACN2_HUMAN (1-444): 2.16e-80: 258: 61.32
+	Mm
		498047 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		PACN1_MOUSE (1-444): 2.72e-92: 287: 95.05
+	Hs
		242924 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		GAS7_HUMAN (15-302): 1.63e-36: 141: 16.44
+	Hs
		496517 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CRKL_HUMAN (366-444): 7.4e-12: 68: 32.91
+	Hs
		497160 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		FBP1L_HUMAN (244-443): 8.15e-10: 62.8: 13.81
+	Hs
		203251 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		PACN1_HUMAN (1-444): 6.15e-95: 294: 100.00
+	Hs
		203262 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		PACN2_HUMAN (1-444): 2.16e-80: 258: 61.32
+	Hs
		203260 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		PACN3_HUMAN (7-444): 2.52e-76: 246: 49.32
+	Hs
		203228 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		ITSN1_HUMAN (367-442): 5.46e-13: 73.6: 31.58