HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: SPTN4 (Q9H254)
Spectrin beta chain, non-erythrocytic 4 (Beta-IV spectrin) (Spectrin, non-erythroid beta chain 3)
Gene: SPTBN4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	26402096, 35063084
Identification Methods	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0043025 - neuronal cell body
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 2564
+	Hs
		211474 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ACTN4_HUMAN (60-639): 2.57e-113: 386: 39.93
+	Hs
		496865 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SPTB2_HUMAN (624-2551): 4.56e-61: 235: 17.42
+	Hs
		164558 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SPTN2_HUMAN (507-2546): 2.8e-51: 203: 18.94
+	Hs
		496988 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SPTN1_HUMAN (259-1728): 1.07e-47: 191: 15.07
+	Rn
		582039 TAU_RAT (1-758): 4.86e-75: 260: 71.47		SPTN2_RAT (507-2552): 4.04e-53: 209: 18.74
+	Rn
		94264 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		SPTN2_RAT (507-2552): 4.04e-53: 209: 18.74
+	Rn
		555250 TAU_RAT (1-758): 4.86e-75: 260: 71.47		SPTN1_RAT (259-1728): 1.37e-47: 191: 15.33
+	Rn
		94140 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		SPTN1_RAT (259-1728): 1.37e-47: 191: 15.33
+	Hs
		497051 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PLEC_HUMAN (233-1186): 4.07e-17: 91.3: 11.29
+	Hs
		496188 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ACTN1_HUMAN (1813-2273): 3.24e-14: 80.9: 10.24
+	Hs
		496176 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DMD_HUMAN (254-1241): 2.74e-09: 65.5: 9.46
+	Dm
		54271 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		A1Z9I8_DROME (506-2350): 4.28e-57: 223: 14.09
+	Hs
		503287 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		PLEC_HUMAN (233-1186): 4.07e-17: 91.3: 11.29
+	Hs
		503257 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		ACTN1_HUMAN (1813-2273): 3.24e-14: 80.9: 10.24