HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: TRI36 (Q9NQ86)
E3 ubiquitin-protein ligase TRIM36 (EC 2.3.2.27) (RING finger protein 98) (RING-type E3 ubiquitin transferase TRIM36) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728)
Gene: TRIM36

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0070507 - regulation of microtubule cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 758 Hs			1 728
+	Hs
		654059 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		TRI36_HUMAN (1-728): 0: 538: 100.00
+	Hs
		503301 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		TRI36_HUMAN (1-728): 0: 538: 100.00
+	Rn
		582028 TAU_RAT (1-758): 4.86e-75: 260: 71.47		TRIM9_RAT (24-720): 1.82e-122: 384: 21.25
+	Rn
		94254 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		TRIM9_RAT (24-720): 1.82e-122: 384: 21.25
+	Hs
		497211 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TRI67_HUMAN (59-721): 1.89e-95: 315: 20.91
+	Hs
		497545 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		FSD1L_HUMAN (223-727): 2.31e-75: 254: 21.06
+	Hs
		497528 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		FSD1_HUMAN (253-721): 1.2e-73: 249: 21.54
+	Hs
		262149 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TRIM3_HUMAN (136-692): 5.7e-67: 236: 12.07
+	Hs
		497564 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TRIM2_HUMAN (119-692): 2.56e-64: 229: 12.00
+	Hs
		496450 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TRI23_HUMAN (18-401): 1.28e-56: 204: 21.60
+	Rn
		250672 TAU_RAT (1-758): 4.86e-75: 260: 71.47		TRIM3_RAT (136-692): 7.59e-65: 231: 12.89
+	Rn
		94106 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		TRIM3_RAT (136-692): 7.59e-65: 231: 12.89
+	Hs
		496954 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TIF1B_HUMAN (25-394): 1.78e-43: 170: 16.36
+	Hs
		654000 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		TRI67_HUMAN (59-721): 1.89e-95: 315: 20.91
+	Hs
		503293 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		TRI67_HUMAN (59-721): 1.89e-95: 315: 20.91
+	Hs
		1056871 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		TRI67_HUMAN (59-721): 1.89e-95: 315: 20.91
+	Hs
		496272 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RO52_HUMAN (29-134): 4.52e-10: 64.8: 14.29
+	Hs
		654076 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		TRI33_HUMAN (32-438): 1.02e-61: 226: 15.79
+	Hs
		1057027 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		TRI33_HUMAN (32-438): 1.02e-61: 226: 15.79
+	Hs
		1029427 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		TIF1B_HUMAN (25-394): 1.78e-43: 170: 16.36