HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: ABI2 (Q9NYB9)
Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1)
Gene: ABI2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0017124 - SH3 domain binding GO:0043197 - dendritic spine
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 513
+	Hs
		497282 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ABI1_HUMAN (1-513): 3.84e-97: 304: 61.00
+	Hs
		203203 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SYNJ1_HUMAN (38-480): 2.57e-33: 137: 12.92
+	Hs
		497012 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SRC8_HUMAN (271-507): 2.78e-32: 131: 17.84
+	Rn
		582013 TAU_RAT (1-758): 4.86e-75: 260: 71.47		SRC8_RAT (228-507): 5.28e-32: 130: 16.07
+	Rn
		94238 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		SRC8_RAT (228-507): 5.28e-32: 130: 16.07
+	Hs
		497000 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ARHG7_HUMAN (451-508): 2.16e-18: 90.8: 41.38
+	Hs
		496788 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		GRB2_HUMAN (454-510): 7.13e-18: 84.5: 37.93
+	Rn
		582007 TAU_RAT (1-758): 4.86e-75: 260: 71.47		SYNJ1_RAT (114-492): 6.54e-09: 61: 12.59
+	Rn
		94231 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		SYNJ1_RAT (114-492): 6.54e-09: 61: 12.59
+	Mm
		88453 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		D3Z656_MOUSE (69-440): 1.05e-09: 63.3: 16.27
+	Hs
		503278 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		GRB2_HUMAN (454-510): 7.13e-18: 84.5: 37.93
+	Hs
		554292 MUC1_HUMAN (242-751): 2.66e-25: 114: 10.84		GRB2_HUMAN (454-510): 7.13e-18: 84.5: 37.93
+	Sp
		194039 YFHH_SCHPO (5-755): 4.88e-12: 72: 8.72		MYO1_SCHPO (306-507): 8.58e-30: 126: 18.45
+	Hs
		203224 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		MYO1E_HUMAN (325-508): 7.96e-32: 132: 22.68
+	Hs
		924760 PRG4_HUMAN (4-604): 5.21e-20: 97.8: 8.93		GRB2_HUMAN (454-510): 7.13e-18: 84.5: 37.93
+	Rn
		192744 SYNJ1_RAT (72-557): 4.95e-13: 75: 12.10		SRBS2_RAT (293-509): 7.62e-17: 85.9: 14.35
+	Hs
		203192 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		SRBS2_HUMAN (373-509): 1.11e-16: 85.5: 19.87
+	Hs
		203218 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		GRB2_HUMAN (454-510): 7.13e-18: 84.5: 37.93
+	Hs
		203228 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		ITSN1_HUMAN (380-510): 4.82e-12: 71: 15.22