HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: MARK1 (Q9P0L2)
Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c)
Gene: MARK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.727

Property	Details
Experiments	21985311, 9614189, 8631898, 10090741, 23666762, 35063084
Identification Methods	enzymatic study, fluorescent resonance energy transfer, anti tag coimmunoprecipitation
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000226 - microtubule cytoskeleton organization GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0010629 - negative regulation of gene expression GO:0015630 - microtubule cytoskeleton and 1 others more... GO:0030425 - dendrite
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 795
+	Hs
		497224 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK2_HUMAN (2-795): 0: 668: 63.76
+	Hs
		496358 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK3_HUMAN (1-795): 0: 664: 63.86
+	Hs
		497452 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK4_HUMAN (1-795): 0: 570: 49.32
+	Hs
		503266 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		MARK3_HUMAN (1-795): 0: 664: 63.86
+	Hs
		497023 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MELK_HUMAN (56-795): 1.01e-161: 485: 25.30
+	Hs
		497840 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SIK3_HUMAN (36-620): 8.16e-139: 444: 36.67
+	Hs
		496670 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SIK1_HUMAN (38-677): 5.5e-142: 439: 31.42
+	Hs
		654032 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		MARK4_HUMAN (1-795): 0: 570: 49.32
+	Hs
		503298 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		MARK4_HUMAN (1-795): 0: 570: 49.32