HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: HECD1 (Q9ULT8)
E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1)
Gene: HECTD1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	26269332
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016607 - nuclear speck
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 2610
+	Hs
		654073 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		HECD1_HUMAN (1-2610): 0: 2419: 100.00
+	Hs
		497461 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		NED4L_HUMAN (2255-2608): 4.26e-117: 399: 21.67
+	Hs
		503303 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		HECW2_HUMAN (1360-2609): 2.26e-127: 444: 14.40
+	Hs
		304168 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		UBR5_HUMAN (1985-2609): 1.07e-116: 418: 16.94
+	Hs
		503299 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		NED4L_HUMAN (2255-2608): 4.26e-117: 399: 21.67
+	Hs
		503297 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		ITCH_HUMAN (2234-2608): 3.18e-117: 398: 21.88
+	Hs
		1170093 SRCAP_HUMAN (2-474): 1.09e-12: 74.3: 9.83		HECW2_HUMAN (1360-2609): 2.26e-127: 444: 14.40
+	Hs
		125172 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		WWP2_HUMAN (2265-2608): 1.64e-107: 368: 24.86
+	Hs
		554367 MUC1_HUMAN (242-751): 2.66e-25: 114: 10.84		WWP1_HUMAN (2328-2608): 5.47e-91: 321: 29.27
+	Hs
		1056563 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		TRIPC_HUMAN (5-1083): 4.48e-58: 225: 14.03
+	Dm
		1182373 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		Q7KU92_DROME (356-967): 3.45e-61: 236: 12.04