HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: G3BP2 (Q9UN86)
Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2)
Gene: G3BP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	26269332, 35063084
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0034063 - stress granule assembly GO:0051260 - protein homooligomerization
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 482
+	Hs
		496955 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Mm
		498011 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		G3BP1_MOUSE (1-455): 2.96e-81: 261: 58.50
+	Hs
		497072 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SAFB1_HUMAN (141-482): 2.07e-42: 163: 16.43
+	Hs
		496725 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		NTF2_HUMAN (4-139): 2.55e-40: 143: 26.47
+	Hs
		653970 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Hs
		311335 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CELF2_HUMAN (309-419): 2e-14: 77.2: 18.10