Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: CHIP (Q9UNE7)
E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)
Gene: STUB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 0.60 0.766

The method score is based on:

Property Details
Experiments 16275660, 23696636, 31320752, 32022419, 32401531, 35107860, 35148989, 36610398, 37086756, 15447663, 20466727, 14612456, 18292230, 14962978, 17304350, 23237806, 23554879
Identification Methods pull down, enzymatic study, unspecified method, affinity chromatography technology, biochemical, anti tag coimmunoprecipitation, filter binding
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0019899 - enzyme binding
and 4 others

more...

Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 758
Hs

1 303
+ Mm
+ Hs
+ Hs
+ Hs
+ Rn
+ Rn
+ Rn
+ Mm
+ Hs
+ Mm
+ Mm
+ Dm
+ Mm
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024