HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: KCC2A (Q9UQM7)
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17)
Gene: CAMK2A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.692

Property	Details
Experiments	36634849, 32812023, 17045592, 17512525
Identification Methods	proximity labelling technology, affinity chromatography technology, enzymatic study, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0043005 - neuron projection and 1 others more... GO:0043197 - dendritic spine
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 478
+	Hs
		496977 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KCC2D_HUMAN (2-476): 0: 552: 87.37
+	Hs
		92372 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		E9PBG7_HUMAN (2-476): 0: 543: 81.69
+	Rn
		506692 TAU_RAT (1-758): 4.86e-75: 260: 71.47		KCC2A_RAT (1-478): 0: 566: 99.79
+	Rn
		94129 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		KCC2A_RAT (1-478): 0: 566: 99.79
+	Rn
		514946 TAU_RAT (1-758): 4.86e-75: 260: 71.47		KCC2G_RAT (1-476): 0: 522: 76.00
+	Rn
		94132 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		KCC2G_RAT (1-476): 0: 522: 76.00
+	Rn
		439487 TAU_RAT (1-758): 4.86e-75: 260: 71.47		KCC2B_RAT (1-476): 1.76e-178: 512: 70.93
+	Rn
		94121 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		KCC2B_RAT (1-476): 1.76e-178: 512: 70.93
+	Mm
		498111 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		KCC2G_MOUSE (1-476): 0: 524: 76.47
+	Mm
		592770 MTAP2_MOUSE (26-758): 1.71e-30: 131: 23.89		KCC2D_MOUSE (2-476): 0: 552: 87.37
+	Rn
		506773 PCLO_RAT (3-721): 3.96e-10: 65.9: 8.48		KCC2A_RAT (1-478): 0: 566: 99.79
+	Hs
		159141 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CSKP_HUMAN (9-307): 2.92e-85: 282: 46.08
+	Hs
		496976 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KCC2B_HUMAN (218-475): 1.27e-60: 211: 42.44