HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: SGT1 (Q9Y2Z0)
Protein SGT1 homolog (Protein 40-6-3) (Sgt1) (Suppressor of G2 allele of SKP1 homolog)
Gene: SUGT1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	35063084, 26269332
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0051087 - protein-folding chaperone binding
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 365
+	Hs
		213466 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SGTA_HUMAN (6-171): 3.42e-40: 146: 20.96
+	Hs
		496621 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PPP5_HUMAN (9-242): 1.39e-38: 145: 14.71
+	Rn
		582023 TAU_RAT (1-758): 4.86e-75: 260: 71.47		TOM70_RAT (2-334): 3.79e-43: 160: 14.80
+	Rn
		94249 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		TOM70_RAT (2-334): 3.79e-43: 160: 14.80
+	Mm
		498036 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		PPP5_MOUSE (9-202): 3.13e-39: 147: 16.58
+	Hs
		174574 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		OGT1_HUMAN (48-303): 5e-18: 87.6: 9.51
+	Hs
		297026 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TOM70_HUMAN (3-221): 1.5e-09: 61.4: 9.29
+	Mm
		592768 MTAP2_MOUSE (26-758): 1.71e-30: 131: 23.89		PPP5_MOUSE (9-202): 3.13e-39: 147: 16.58
+	Dm
		1366837 Q9VPR2_DROME (127-757): 2.65e-20: 98.2: 10.23		Q9VH81_DROME (4-218): 1.63e-39: 148: 13.58
+	Mm
		88457 D3Z656_MOUSE (72-555): 1.33e-11: 70.4: 11.56		PPP5_MOUSE (9-202): 3.13e-39: 147: 16.58
+	Hs
		174891 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		OGT1_HUMAN (48-303): 5e-18: 87.6: 9.51
+	Hs
		175053 KMT2C_HUMAN (83-649): 6.28e-09: 61.8: 12.91		OGT1_HUMAN (48-303): 5e-18: 87.6: 9.51