HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: TLN2 (Q9Y4G6)
Talin-2
Gene: TLN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	26269332, 35063084
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 2542
+	Hs
		497870 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TLN1_HUMAN (1-2540): 0: 1092: 76.05
+	Dm
		1370280 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		Q9VSL8_DROME (1-2529): 0: 1034: 47.05
+	Hs
		124366 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		HIP1_HUMAN (1819-2542): 1.57e-110: 382: 18.79
+	Hs
		496224 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		EZRI_HUMAN (86-669): 5.11e-114: 378: 15.90
+	Hs
		496432 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MERL_HUMAN (82-653): 1.99e-94: 321: 14.97
+	Hs
		496433 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RADI_HUMAN (86-669): 3.67e-91: 311: 15.06
+	Hs
		496340 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MOES_HUMAN (86-669): 6.9e-90: 307: 14.66
+	Hs
		497598 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		E41L1_HUMAN (36-735): 1.84e-74: 270: 12.36
+	Hs
		203207 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		EZRI_HUMAN (86-669): 5.11e-114: 378: 15.90
+	Hs
		297816 K0754_HUMAN (5-450): 2.95e-22: 105: 11.86		RADI_HUMAN (86-669): 3.67e-91: 311: 15.06
+	Hs
		497769 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MYH2_HUMAN (746-1815): 9.7e-23: 109: 8.81
+	Hs
		503282 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		MYO7A_HUMAN (85-368): 1.74e-14: 82.2: 17.23
+	Ce
		136791 UNC89_CAEEL (4-459): 4.47e-21: 101: 12.37		HUM6_CAEEL (80-424): 1.7e-20: 102: 21.27