HitPredict

Interactor 1: TAU (P10637)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: Mapt

Interactor 2: AP2B1 (Q9DBG3)
AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
Gene: AP2B1

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	30068389
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0009898 - cytoplasmic side of plasma membrane GO:0044877 - protein-containing complex binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 733 Mm			1 937
+	Rn
		581970 TAU_RAT (1-733): 1.67e-78: 268: 88.46		AP2B1_RAT (1-937): 0: 924: 99.89
+	Rn
		94193 F1LST4_RAT (1-732): 4.29e-78: 268: 88.58		AP2B1_RAT (1-937): 0: 924: 99.89
+	Hs
		496790 TAU_HUMAN (1-733): 3.71e-62: 224: 69.50		AP2B1_HUMAN (1-937): 0: 924: 99.89
+	Hs
		496926 TAU_HUMAN (1-733): 3.71e-62: 224: 69.50		AP1B1_HUMAN (1-937): 0: 887: 82.72
+	Hs
		926047 MAGL2_HUMAN (31-705): 3.72e-10: 65.8: 11.03		AP2B1_HUMAN (1-937): 0: 924: 99.89
+	Hs
		203219 SYNJ1_HUMAN (336-712): 5.99e-10: 65: 13.02		AP2B1_HUMAN (1-937): 0: 924: 99.89
+	Hs
		203223 SYNJ1_HUMAN (336-712): 5.99e-10: 65: 13.02		AP1B1_HUMAN (1-937): 0: 887: 82.72
+	Mm
		497920 TAU_MOUSE (1-733): 4.79e-86: 288: 100.00		AP2A1_MOUSE (11-932): 0: 633: 16.94
+	Rn
		577190 TAU_RAT (1-733): 1.67e-78: 268: 88.46		AP2A2_RAT (11-932): 0: 600: 16.29
+	Rn
		94239 F1LST4_RAT (1-732): 4.29e-78: 268: 88.58		Q66HM2_RAT (11-932): 0: 595: 16.17
+	Hs
		321471 TAU_HUMAN (1-733): 3.71e-62: 224: 69.50		AP2A1_HUMAN (11-932): 0: 634: 16.77
+	Hs
		302095 TAU_HUMAN (1-733): 3.71e-62: 224: 69.50		AP2A2_HUMAN (11-933): 0: 604: 16.89
+	Mm
		498147 TAU_MOUSE (1-733): 4.79e-86: 288: 100.00		AP3B2_MOUSE (16-594): 2.81e-173: 534: 28.71
+	Hs
		496624 TAU_HUMAN (1-733): 3.71e-62: 224: 69.50		COPB_HUMAN (8-927): 0: 567: 12.88
+	Hs
		212589 TAU_HUMAN (1-733): 3.71e-62: 224: 69.50		AP1G1_HUMAN (11-808): 0: 549: 17.57
+	Hs
		203194 SYNJ1_HUMAN (336-712): 5.99e-10: 65: 13.02		AP2A1_HUMAN (11-932): 0: 634: 16.77
+	Hs
		496962 TAU_HUMAN (1-733): 3.71e-62: 224: 69.50		AP3B2_HUMAN (16-595): 1.09e-150: 475: 28.19
+	Rn
		1144064 SYNJ1_RAT (391-730): 7.57e-09: 61.6: 10.22		Q66HM2_RAT (11-932): 0: 595: 16.17