HitPredict

Interactor 1: TAU (P10637)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: Mapt

Interactor 2: CHIP (Q9WUD1)
E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)
Gene: Stub1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14962978
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031072 - heat shock protein binding GO:0051087 - protein-folding chaperone binding and 1 others more... GO:0051879 - Hsp90 protein binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 733 Mm			1 304
+	Hs
		497799 TAU_HUMAN (1-733): 3.71e-62: 224: 69.50		CHIP_HUMAN (1-304): 9.07e-67: 212: 97.04
+	Rn
		582023 TAU_RAT (1-733): 1.67e-78: 268: 88.46		TOM70_RAT (5-218): 3.84e-46: 166: 22.79
+	Rn
		94249 F1LST4_RAT (1-732): 4.29e-78: 268: 88.58		TOM70_RAT (5-218): 3.84e-46: 166: 22.79
+	Mm
		498036 TAU_MOUSE (1-733): 4.79e-86: 288: 100.00		PPP5_MOUSE (1-260): 4.53e-36: 137: 20.38
+	Hs
		496621 TAU_HUMAN (1-733): 3.71e-62: 224: 69.50		PPP5_HUMAN (1-260): 1.89e-35: 135: 20.76
+	Rn
		193483 TAU_RAT (1-733): 1.67e-78: 268: 88.46		STIP1_RAT (3-263): 2.68e-12: 68.9: 10.14
+	Rn
		94104 F1LST4_RAT (1-732): 4.29e-78: 268: 88.58		STIP1_RAT (3-263): 2.68e-12: 68.9: 10.14
+	Hs
		174574 TAU_HUMAN (1-733): 3.71e-62: 224: 69.50		OGT1_HUMAN (3-259): 1.13e-22: 100: 11.97
+	Hs
		496417 TAU_HUMAN (1-733): 3.71e-62: 224: 69.50		STIP1_HUMAN (3-263): 8.89e-13: 70.4: 10.14
+	Hs
		297026 TAU_HUMAN (1-733): 3.71e-62: 224: 69.50		TOM70_HUMAN (5-239): 1.4e-10: 63.6: 16.73
+	Hs
		213466 TAU_HUMAN (1-733): 3.71e-62: 224: 69.50		SGTA_HUMAN (72-173): 1.97e-09: 59.6: 15.69
+	Dm
		375660 RPB1_DROME (89-504): 7.96e-29: 126: 13.40		Q9VH81_DROME (6-247): 2.21e-43: 157: 18.03
+	Mm
		592768 MTAP2_MOUSE (21-733): 1.11e-34: 144: 24.55		PPP5_MOUSE (1-260): 4.53e-36: 137: 20.38
+	Dm
		375655 RPB1_DROME (89-504): 7.96e-29: 126: 13.40		Q9V3E9_DROME (10-252): 7.2e-34: 131: 17.48
+	Dm
		1366837 Q9VPR2_DROME (173-706): 2.82e-13: 75.4: 10.60		Q9VH81_DROME (6-247): 2.21e-43: 157: 18.03
+	Hs
		174891 MDC1_HUMAN (2-721): 9.17e-27: 119: 9.02		OGT1_HUMAN (3-259): 1.13e-22: 100: 11.97
+	Dm
		1358474 Q9VLS7_DROME (23-733): 1.82e-11: 70.1: 10.76		Q9V3E9_DROME (10-252): 7.2e-34: 131: 17.48
+	Mm
		88457 D3Z656_MOUSE (4-352): 4.88e-09: 62: 9.87		PPP5_MOUSE (1-260): 4.53e-36: 137: 20.38
+	Hs
		175053 KMT2C_HUMAN (10-696): 1.37e-11: 70.4: 9.61		OGT1_HUMAN (3-259): 1.13e-22: 100: 11.97
+	Mm
		1100610 PK1L3_MOUSE (342-729): 3.15e-14: 79.2: 10.91		WDTC1_MOUSE (25-140): 3.28e-09: 59.7: 31.50