HitPredict - High confidence protein-protein interactions

Interactor 1: KAP0 (P10644)
cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1)
Gene: PRKAR1A

Interactor 2: KAP0 (P10644)
cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1)
Gene: PRKAR1A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.888

Property	Details
Experiments	12634056, 31980649, 20133847, 31515488
Identification Methods	affinity chromatography technology, two hybrid, bimolecular fluorescence complementation, two hybrid array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	cNMP_binding~cNMP_binding, RIIa~RIIa
Common GO terms	GO:0001707 - mesoderm formation GO:0004862 - cAMP-dependent protein kinase inhibitor activity GO:0005737 - cytoplasm GO:0005771 - multivesicular body GO:0005813 - centrosome and 24 others more... GO:0005829 - cytosol GO:0005952 - cAMP-dependent protein kinase complex GO:0006357 - regulation of transcription by RNA polymerase II GO:0007189 - adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0008603 - cAMP-dependent protein kinase regulator activity GO:0010629 - negative regulation of gene expression GO:0016020 - membrane GO:0019904 - protein domain specific binding GO:0030552 - cAMP binding GO:0031588 - nucleotide-activated protein kinase complex GO:0031594 - neuromuscular junction GO:0031625 - ubiquitin protein ligase binding GO:0032024 - positive regulation of insulin secretion GO:0032991 - protein-containing complex GO:0034236 - protein kinase A catalytic subunit binding GO:0035556 - intracellular signal transduction GO:0044853 - plasma membrane raft GO:0045214 - sarcomere organization GO:0046007 - negative regulation of activated T cell proliferation GO:0060038 - cardiac muscle cell proliferation GO:0071377 - cellular response to glucagon stimulus GO:0097546 - ciliary base GO:0098978 - glutamatergic synapse GO:2000480 - negative regulation of cAMP-dependent protein kinase activity
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1	381
Hs

1	381

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Last updated: 15 Jul 2024