HitPredict

Interactor 1: KAP0 (P10644)
cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1)
Gene: PRKAR1A

Interactor 2: KPCA (P17252)
Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13)
Gene: PRKCA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	31980649, 36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~cNMP_binding, Pkinase~RIIa
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0035556 - intracellular signal transduction
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 381 Hs			1 672
+	Hs
		566299 KAP1_HUMAN (1-381): 1.35e-138: 401: 81.37		KPCA_HUMAN (1-672): 0: 794: 100.00
+	Mm
		522342 KAP1_MOUSE (1-381): 2.29e-142: 410: 81.37		KPCB_MOUSE (1-664): 0: 747: 79.34
+	Hs
		408539 KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00		KPCB_HUMAN (1-664): 0: 749: 78.89
+	Mm
		522340 KAP1_MOUSE (1-381): 2.29e-142: 410: 81.37		KPCG_MOUSE (16-670): 0: 698: 69.88
+	Hs
		566300 KAP3_HUMAN (10-253): 4.9e-21: 95.9: 18.21		KPCA_HUMAN (1-672): 0: 794: 100.00
+	Hs
		533779 KAP2_HUMAN (233-379): 1.21e-17: 85.5: 26.53		KPCA_HUMAN (1-672): 0: 794: 100.00
+	Hs
		498221 KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00		AKT1_HUMAN (243-660): 2.07e-155: 459: 37.36
+	Hs
		498225 KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00		KPCI_HUMAN (22-86): 8.63e-12: 70.1: 43.08
+	Hs
		498257 KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00		KPCZ_HUMAN (22-98): 3.2e-11: 68.6: 34.44