HitPredict

Interactor 1: KAP0 (P10644)
cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1)
Gene: PRKAR1A

Interactor 2: KAPCA (P17612)
cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11)
Gene: PRKACA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.988

The method score is based on:

Property Details
Experiments 26186194, 28514442, 17353931, 33961781, 16376338, 32296183, 33957083, 21614075, 35271311, 32707033, 30274258, 23455922, 24700472, 24855271, unassigned1304, unassigned2173, 15655353
Identification Methods affinity chromatography technology, pull down, two hybrid, proximity labelling technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, two hybrid array, validated two hybrid, two hybrid prey pooling approach, coimmunoprecipitation and 1 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~cNMP_binding, Pkinase~RIIa
Common GO terms GO:0001707 - mesoderm formation
GO:0005737 - cytoplasm
GO:0005813 - centrosome
GO:0005829 - cytosol
GO:0005952 - cAMP-dependent protein kinase complex
and 10 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 381
Hs

1 351
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+ Bt
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024