HitPredict

Interactor 1: KAP0 (P10644)
cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1)
Gene: PRKAR1A

Interactor 2: KAPCB (P22694)
cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11)
Gene: PRKACB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.972

Property	Details
Experiments	26186194, 31980649, 28514442, 33961781, 32707033, 36736316, 23455922, unassigned2173, 21880142
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, pull down, two hybrid, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~cNMP_binding, Pkinase~RIIa
Common GO terms	GO:0005813 - centrosome GO:0005829 - cytosol GO:0005952 - cAMP-dependent protein kinase complex GO:0031625 - ubiquitin protein ligase binding GO:0097546 - ciliary base
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 381 Hs			1 351
+	Mm
		397222 KAP0_MOUSE (1-381): 2.58e-141: 408: 96.85		KAPCA_MOUSE (1-351): 1.06e-162: 460: 92.02
+	Hs
		498202 KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00		KAPCA_HUMAN (1-351): 3.72e-164: 463: 92.88
+	Hs
		610685 KAP1_HUMAN (1-381): 1.35e-138: 401: 81.37		KAPCB_HUMAN (1-351): 1.47e-164: 464: 100.00
+	Hs
		568558 KAP1_HUMAN (1-381): 1.35e-138: 401: 81.37		KAPCA_HUMAN (1-351): 3.72e-164: 463: 92.88
+	Hs
		498208 KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00		KAPCG_HUMAN (1-351): 5.62e-161: 456: 78.63
+	Hs
		609646 KAP1_HUMAN (1-381): 1.35e-138: 401: 81.37		KAPCG_HUMAN (1-351): 5.62e-161: 456: 78.63
+	Hs
		498221 KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00		AKT1_HUMAN (2-347): 4.4e-147: 425: 39.03
+	Dm
		519451 KAPR1_DROME (6-381): 8.96e-131: 381: 71.54		KAPC1_DROME (1-351): 1.75e-155: 442: 81.59
+	Hs
		498234 KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00		PRKX_HUMAN (8-351): 7.27e-144: 412: 49.13
+	Dm
		519457 KAPR2_DROME (27-377): 8.76e-104: 312: 37.85		KAPC1_DROME (1-351): 1.75e-155: 442: 81.59
+	Sc
		412617 KAPR_YEAST (81-369): 6.42e-86: 268: 37.24		KAPA_YEAST (3-351): 1.46e-145: 418: 45.17
+	Sc
		412929 KAPR_YEAST (81-369): 6.42e-86: 268: 37.24		KAPB_YEAST (25-351): 1.86e-145: 417: 50.61
+	Sc
		409586 KAPR_YEAST (81-369): 6.42e-86: 268: 37.24		KAPC_YEAST (33-351): 5.65e-143: 412: 48.76
+	Sp
		736930 KAPR_SCHPO (28-369): 1.79e-75: 241: 28.79		KAPB_SCHPO (24-343): 3.31e-140: 409: 50.00
+	Ca
		1124295 KAPR_CANAL (43-369): 5.79e-68: 223: 34.65		Q5AP71_CANAL (23-351): 1.41e-141: 408: 46.41
+	Hs
		568559 KAP3_HUMAN (10-253): 4.9e-21: 95.9: 18.21		KAPCA_HUMAN (1-351): 3.72e-164: 463: 92.88
+	Mm
		397199 KAP3_MOUSE (10-253): 2.54e-21: 96.6: 18.57		KAPCA_MOUSE (1-351): 1.06e-162: 460: 92.02
+	Hs
		1047564 KGP1_HUMAN (118-320): 1.3e-22: 101: 21.53		KGP1_HUMAN (38-335): 1.91e-90: 286: 46.21
+	Bt
		337287 KGP1_BOVIN (118-320): 1.23e-22: 101: 21.53		KGP1_BOVIN (38-335): 2.31e-90: 286: 46.21
+	Hs
		217858 KAP3_HUMAN (10-253): 4.9e-21: 95.9: 18.21		PRKY_HUMAN (41-267): 4.53e-93: 280: 54.63