HitPredict

Interactor 1: KAP0 (P10644)
cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1)
Gene: PRKAR1A

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	9050991
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 381 Hs			1 217
+	Hs
		498275 KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00		PTK6_HUMAN (4-141): 7.14e-23: 97.1: 38.93
+	Hs
		411961 KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		924940 HCN2_HUMAN (246-369): 2.16e-30: 124: 21.77		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		337604 HCN4_HUMAN (246-369): 1.72e-30: 125: 21.77		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		337588 HCN2_HUMAN (246-369): 2.16e-30: 124: 21.77		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		412422 HCN4_HUMAN (246-369): 1.72e-30: 125: 21.77		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		412401 HCN2_HUMAN (246-369): 2.16e-30: 124: 21.77		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Mm
		292104 HCN2_MOUSE (238-369): 1.34e-32: 131: 20.46		SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		523195 HCN2_HUMAN (246-369): 2.16e-30: 124: 21.77		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		679335 KAP3_HUMAN (10-253): 4.9e-21: 95.9: 18.21		VAV2_HUMAN (3-56): 4.83e-11: 63.5: 38.18