HitPredict

Interactor 1: KAP0 (P10644)
cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1)
Gene: PRKAR1A

Interactor 2: KPCZ (Q05513)
Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)
Gene: PRKCZ

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~cNMP_binding, Pkinase~RIIa
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0035556 - intracellular signal transduction GO:0098978 - glutamatergic synapse
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 381 Hs			1 592
+	Hs
		498225 KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00		KPCI_HUMAN (1-592): 0: 654: 69.87
+	Hs
		498221 KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00		AKT1_HUMAN (172-582): 1.55e-153: 451: 36.39
+	Hs
		498202 KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00		KAPCA_HUMAN (219-578): 5.07e-143: 419: 33.06
+	Hs
		568558 KAP1_HUMAN (1-381): 1.35e-138: 401: 81.37		KAPCA_HUMAN (219-578): 5.07e-143: 419: 33.06
+	Hs
		498233 KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00		KS6A3_HUMAN (168-539): 2.67e-105: 335: 20.47
+	Hs
		568559 KAP3_HUMAN (10-253): 4.9e-21: 95.9: 18.21		KAPCA_HUMAN (219-578): 5.07e-143: 419: 33.06
+	Mm
		522342 KAP1_MOUSE (1-381): 2.29e-142: 410: 81.37		KPCB_MOUSE (85-187): 9.6e-22: 101: 27.18
+	Hs
		408539 KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00		KPCB_HUMAN (85-187): 1.04e-21: 101: 27.18
+	Hs
		533780 KAP2_HUMAN (233-379): 1.21e-17: 85.5: 26.53		KAPCA_HUMAN (219-578): 5.07e-143: 419: 33.06
+	Hs
		498201 KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00		KPCA_HUMAN (101-181): 1.39e-16: 85.3: 29.63
+	Hs
		566299 KAP1_HUMAN (1-381): 1.35e-138: 401: 81.37		KPCA_HUMAN (101-181): 1.39e-16: 85.3: 29.63
+	Mm
		522340 KAP1_MOUSE (1-381): 2.29e-142: 410: 81.37		KPCG_MOUSE (116-180): 1.79e-10: 65.9: 36.92
+	Hs
		566300 KAP3_HUMAN (10-253): 4.9e-21: 95.9: 18.21		KPCA_HUMAN (101-181): 1.39e-16: 85.3: 29.63
+	Hs
		533779 KAP2_HUMAN (233-379): 1.21e-17: 85.5: 26.53		KPCA_HUMAN (101-181): 1.39e-16: 85.3: 29.63