HitPredict

Interactor 1: KAP0 (P10644)
cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1)
Gene: PRKAR1A

Interactor 2: BIG2 (Q9Y6D5)
Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2)
Gene: ARFGEF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.636

Property	Details
Experiments	12571360, 19332778
Identification Methods	pull down, affinity chromatography technology, two hybrid, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005813 - centrosome GO:0005829 - cytosol GO:0016020 - membrane GO:0035556 - intracellular signal transduction GO:0098978 - glutamatergic synapse
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 381 Hs			1 1785
+	Hs
		498387 KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00		BIG1_HUMAN (5-1773): 0: 1816: 73.84
+	Hs
		679417 KAP3_HUMAN (10-253): 4.9e-21: 95.9: 18.21		BIG2_HUMAN (1-1785): 0: 1997: 100.00
+	Hs
		533891 KAP2_HUMAN (233-379): 1.21e-17: 85.5: 26.53		BIG2_HUMAN (1-1785): 0: 1997: 100.00