HitPredict

Interactor 1: PLCG1 (P10686)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-gamma-1) (PLC-gamma-1)
Gene: PLCG1

Interactor 2: INSR (P15127)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Species: Rattus norvegicus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	11796522
Identification Methods	coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, SH2~fn3, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1290 Rn			1 1383
+	Hs
		411292 PLCG1_HUMAN (1-1290): 0: 1269: 96.90		INSR_HUMAN (27-1383): 0: 1527: 95.43
+	Hs
		580937 PLCG1_HUMAN (1-1290): 0: 1269: 96.90		EPHB2_HUMAN (662-1317): 0: 577: 23.01
+	Hs
		580965 PLCG1_HUMAN (1-1290): 0: 1269: 96.90		EPHA4_HUMAN (662-1328): 0: 570: 24.19
+	Hs
		581078 PLCG1_HUMAN (1-1290): 0: 1269: 96.90		ALK_HUMAN (997-1340): 6.12e-71: 264: 41.57
+	Rn
		499163 PLCG1_RAT (1-1290): 0: 1287: 100.00		NTRK2_RAT (997-1293): 1.74e-66: 244: 42.38
+	Mm
		546302 PLCG1_MOUSE (1-1280): 0: 1281: 98.91		NTRK2_MOUSE (997-1293): 1.64e-66: 244: 42.38
+	Hs
		580940 PLCG1_HUMAN (1-1290): 0: 1269: 96.90		LTK_HUMAN (1014-1292): 4.56e-70: 255: 43.82
+	Mm
		1112476 PLCG1_MOUSE (1-1280): 0: 1281: 98.91		NTRK1_MOUSE (997-1287): 2.13e-65: 240: 41.61
+	Hs
		581014 PLCG1_HUMAN (1-1290): 0: 1269: 96.90		NTRK2_HUMAN (997-1293): 1.8e-67: 246: 42.72
+	Hs
		384239 PLCG1_HUMAN (1-1290): 0: 1269: 96.90		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		581012 PLCG1_HUMAN (1-1290): 0: 1269: 96.90		NTRK3_HUMAN (997-1291): 5.26e-62: 230: 38.80
+	Hs
		580927 PLCG1_HUMAN (1-1290): 0: 1269: 96.90		FGFR3_HUMAN (1016-1288): 2.88e-60: 224: 40.07
+	Hs
		580925 PLCG1_HUMAN (1-1290): 0: 1269: 96.90		ERBB3_HUMAN (5-368): 5.74e-31: 135: 19.70
+	Hs
		337912 PLCG1_HUMAN (1-1290): 0: 1269: 96.90		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		581010 PLCG1_HUMAN (1-1290): 0: 1269: 96.90		ERBB4_HUMAN (44-347): 2.97e-26: 119: 20.42
+	Hs
		383601 PLCG1_HUMAN (1-1290): 0: 1269: 96.90		ERBB2_HUMAN (32-342): 4.75e-18: 92.8: 19.83
+	Mm
		1141452 PLCG2_MOUSE (19-1285): 0: 1111: 50.20		MERTK_MOUSE (835-1301): 5.85e-61: 229: 32.35
+	Hs
		562623 PLCG2_HUMAN (18-1285): 0: 1108: 49.61		ERBB3_HUMAN (5-368): 5.74e-31: 135: 19.70
+	Hs
		337886 PLCG2_HUMAN (18-1285): 0: 1108: 49.61		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		383591 PLCG2_HUMAN (18-1285): 0: 1108: 49.61		ERBB2_HUMAN (32-342): 4.75e-18: 92.8: 19.83