HitPredict

Interactor 1: PLCG1 (P10686)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-gamma-1) (PLC-gamma-1)
Gene: PLCG1

Interactor 2: GRB2 (P62994)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Rattus norvegicus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.50 1.00 0.714

The method score is based on:

Property Details
Experiments 16038803, 9281317
Identification Methods unspecified method, coimmunoprecipitation
Interaction Type direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains C2~SH2, PH~SH3_1, SH2~SH2, SH2~SH3_1, SH3_1~SH3_1
Common GO terms GO:0005168 - neurotrophin TRKA receptor binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005911 - cell-cell junction
and 4 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1290
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024