HitPredict

Interactor 1: PF4V (P10720)
Platelet factor 4 variant (C-X-C motif chemokine 4 variant) (CXCL4L1) (PF4alt) (PF4var1) [Cleaved into: Platelet factor 4 variant(4-74); Platelet factor 4 variant(5-74); Platelet factor 4 variant(6-74)]
Gene: PF4V1

Interactor 2: CC4L (Q8NHW4)
C-C motif chemokine 4-like (Lymphocyte activation gene 1 protein) (LAG-1) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (Monocyte adherence-induced protein 5-alpha) (Small-inducible cytokine A4-like)
Gene: CCL4L1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	28381538
Identification Methods	pull down, filter binding
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	IL8~IL8
Common GO terms	GO:0005615 - extracellular space GO:0006954 - inflammatory response GO:0008009 - chemokine activity GO:0030593 - neutrophil chemotaxis GO:0070098 - chemokine-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 104 Hs			1 92
+	Hs
		499207 PF4V_HUMAN (1-104): 3.07e-33: 112: 100.00		CCL11_HUMAN (1-91): 5.09e-27: 96.2: 40.22
+	Hs
		587776 CXCL2_HUMAN (33-104): 4.01e-28: 99.7: 38.89		CCL8_HUMAN (1-91): 2.83e-31: 106: 39.13
+	Hs
		499218 PF4V_HUMAN (1-104): 3.07e-33: 112: 100.00		CCL26_HUMAN (23-90): 2.58e-24: 89.2: 48.53
+	Hs
		791124 CXCL5_HUMAN (24-103): 3.7e-30: 105: 38.75		CCL11_HUMAN (1-91): 5.09e-27: 96.2: 40.22
+	Hs
		528237 CXCL2_HUMAN (33-104): 4.01e-28: 99.7: 38.89		CCL5_HUMAN (1-92): 1.07e-27: 97.7: 44.57
+	Hs
		587775 CXCL2_HUMAN (33-104): 4.01e-28: 99.7: 38.89		CCL11_HUMAN (1-91): 5.09e-27: 96.2: 40.22
+	Hs
		448992 GROA_HUMAN (38-104): 1.7e-27: 98.2: 43.28		CCL11_HUMAN (1-91): 5.09e-27: 96.2: 40.22
+	Hs
		134720 PF4V_HUMAN (1-104): 3.07e-33: 112: 100.00		CCL22_HUMAN (21-91): 1.88e-21: 81.9: 34.72
+	Hs
		499205 PF4V_HUMAN (1-104): 3.07e-33: 112: 100.00		XCL1_HUMAN (1-91): 1.2e-20: 80.8: 29.67
+	Hs
		499217 PF4V_HUMAN (1-104): 3.07e-33: 112: 100.00		XCL2_HUMAN (1-91): 1.43e-20: 80.4: 29.67
+	Hs
		499215 PF4V_HUMAN (1-104): 3.07e-33: 112: 100.00		CCL19_HUMAN (17-91): 1e-19: 77.7: 33.77
+	Hs
		791136 CXCL5_HUMAN (24-103): 3.7e-30: 105: 38.75		XCL2_HUMAN (1-91): 1.43e-20: 80.4: 29.67
+	Hs
		134287 PF4V_HUMAN (1-104): 3.07e-33: 112: 100.00		CCL21_HUMAN (33-90): 3.55e-17: 72.3: 40.32
+	Hs
		179463 PF4V_HUMAN (1-104): 3.07e-33: 112: 100.00		CCL25_HUMAN (7-90): 5.37e-16: 69.6: 23.91
+	Hs
		587772 CXCL2_HUMAN (33-104): 4.01e-28: 99.7: 38.89		XCL1_HUMAN (1-91): 1.2e-20: 80.8: 29.67
+	Hs
		587784 CXCL2_HUMAN (33-104): 4.01e-28: 99.7: 38.89		XCL2_HUMAN (1-91): 1.43e-20: 80.4: 29.67
+	Hs
		791125 CXCL5_HUMAN (24-103): 3.7e-30: 105: 38.75		CCL20_HUMAN (3-90): 8.4e-17: 70.4: 30.00
+	Hs
		134290 CXCL2_HUMAN (33-104): 4.01e-28: 99.7: 38.89		CCL21_HUMAN (33-90): 3.55e-17: 72.3: 40.32
+	Hs
		134284 PLF4_HUMAN (12-104): 1.82e-27: 98.2: 89.25		CCL21_HUMAN (33-90): 3.55e-17: 72.3: 40.32
+	Hs
		179462 PLF4_HUMAN (12-104): 1.82e-27: 98.2: 89.25		CCL25_HUMAN (7-90): 5.37e-16: 69.6: 23.91