HitPredict

Interactor 1: PF4V (P10720)
Platelet factor 4 variant (C-X-C motif chemokine 4 variant) (CXCL4L1) (PF4alt) (PF4var1) [Cleaved into: Platelet factor 4 variant(4-74); Platelet factor 4 variant(5-74); Platelet factor 4 variant(6-74)]
Gene: PF4V1

Interactor 2: CCL19 (Q99731)
C-C motif chemokine 19 (Beta-chemokine exodus-3) (CK beta-11) (Epstein-Barr virus-induced molecule 1 ligand chemokine) (EBI1 ligand chemokine) (ELC) (Macrophage inflammatory protein 3 beta) (MIP-3-beta) (Small-inducible cytokine A19)
Gene: CCL19

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	28381538
Identification Methods	pull down, filter binding
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	IL8~IL8
Common GO terms	GO:0005615 - extracellular space GO:0006954 - inflammatory response GO:0008009 - chemokine activity GO:0030593 - neutrophil chemotaxis GO:0070098 - chemokine-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 104 Hs			1 98
+	Hs
		499207 PF4V_HUMAN (1-104): 3.07e-33: 112: 100.00		CCL11_HUMAN (14-95): 5.97e-28: 99: 23.17
+	Hs
		499212 PF4V_HUMAN (1-104): 3.07e-33: 112: 100.00		CC4L_HUMAN (8-89): 2.3e-27: 97.4: 30.49
+	Hs
		179463 PF4V_HUMAN (1-104): 3.07e-33: 112: 100.00		CCL25_HUMAN (3-91): 4.97e-25: 93.2: 25.81
+	Hs
		791124 CXCL5_HUMAN (24-103): 3.7e-30: 105: 38.75		CCL11_HUMAN (14-95): 5.97e-28: 99: 23.17
+	Hs
		499217 PF4V_HUMAN (1-104): 3.07e-33: 112: 100.00		XCL2_HUMAN (3-96): 8.99e-24: 89: 24.21
+	Hs
		499205 PF4V_HUMAN (1-104): 3.07e-33: 112: 100.00		XCL1_HUMAN (3-96): 1.01e-23: 88.6: 24.21
+	Hs
		134287 PF4V_HUMAN (1-104): 3.07e-33: 112: 100.00		CCL21_HUMAN (19-95): 6.89e-23: 87: 34.18
+	Hs
		587775 CXCL2_HUMAN (33-104): 4.01e-28: 99.7: 38.89		CCL11_HUMAN (14-95): 5.97e-28: 99: 23.17
+	Hs
		499218 PF4V_HUMAN (1-104): 3.07e-33: 112: 100.00		CCL26_HUMAN (19-91): 8.81e-23: 85.9: 30.14
+	Hs
		448992 GROA_HUMAN (38-104): 1.7e-27: 98.2: 43.28		CCL11_HUMAN (14-95): 5.97e-28: 99: 23.17
+	Hs
		587776 CXCL2_HUMAN (33-104): 4.01e-28: 99.7: 38.89		CCL8_HUMAN (13-95): 3.44e-27: 97: 24.71
+	Hs
		791136 CXCL5_HUMAN (24-103): 3.7e-30: 105: 38.75		XCL2_HUMAN (3-96): 8.99e-24: 89: 24.21
+	Hs
		179462 PLF4_HUMAN (12-104): 1.82e-27: 98.2: 89.25		CCL25_HUMAN (3-91): 4.97e-25: 93.2: 25.81
+	Hs
		791125 CXCL5_HUMAN (24-103): 3.7e-30: 105: 38.75		CCL20_HUMAN (3-93): 2.11e-22: 84.7: 29.67
+	Hs
		587784 CXCL2_HUMAN (33-104): 4.01e-28: 99.7: 38.89		XCL2_HUMAN (3-96): 8.99e-24: 89: 24.21
+	Hs
		587772 CXCL2_HUMAN (33-104): 4.01e-28: 99.7: 38.89		XCL1_HUMAN (3-96): 1.01e-23: 88.6: 24.21
+	Hs
		528237 CXCL2_HUMAN (33-104): 4.01e-28: 99.7: 38.89		CCL5_HUMAN (11-89): 1.78e-23: 87.4: 30.38
+	Hs
		134290 CXCL2_HUMAN (33-104): 4.01e-28: 99.7: 38.89		CCL21_HUMAN (19-95): 6.89e-23: 87: 34.18
+	Hs
		134720 PF4V_HUMAN (1-104): 3.07e-33: 112: 100.00		CCL22_HUMAN (29-88): 2.54e-18: 74.3: 33.33
+	Hs
		134284 PLF4_HUMAN (12-104): 1.82e-27: 98.2: 89.25		CCL21_HUMAN (19-95): 6.89e-23: 87: 34.18