HitPredict

Interactor 1: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Interactor 2: PGFRA (P16234)
Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
Gene: PDGFRA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.618

The method score is based on:

Property Details
Experiments 17452978
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains ig~I-set, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr
Common GO terms GO:0002244 - hematopoietic progenitor cell differentiation
GO:0004714 - transmembrane receptor protein tyrosine kinase activity
GO:0005524 - ATP binding
GO:0005886 - plasma membrane
GO:0009897 - external side of plasma membrane
and 6 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 976
Hs

1 1089
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+ Mm
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+ Rn
+ Mm
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+ Dr
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024