HitPredict

Interactor 1: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Interactor 2: PLCG1 (P19174)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
Gene: PLCG1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.918

Property	Details
Experiments	11071635, 24728074, 14647465, 7536744, 7537096
Identification Methods	pull down, affinity chromatography technology, coimmunoprecipitation, fluorescence polarization spectroscopy
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0005911 - cell-cell junction
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 976 Hs			1 1290
+	Hs
		499228 KIT_HUMAN (1-976): 0: 807: 100.00		PLCG2_HUMAN (18-1287): 0: 1128: 49.45
+	Hs
		452348 PGFRB_HUMAN (30-954): 0: 591: 30.62		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Mm
		404014 PGFRB_MOUSE (14-974): 0: 597: 29.51		PLCG1_MOUSE (1-1288): 0: 1302: 96.12
+	Hs
		580923 FGFR2_HUMAN (8-323): 1.59e-55: 209: 13.10		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Hs
		580927 FGFR3_HUMAN (3-331): 4.6e-51: 195: 13.39		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Hs
		580926 FGFR4_HUMAN (4-224): 3.99e-23: 107: 13.21		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Hs
		507843 FGFR1_HUMAN (4-235): 6.88e-22: 104: 13.25		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Rn
		499160 FGFR1_RAT (4-235): 6.64e-22: 104: 12.91		PLCG1_RAT (1-1290): 0: 1299: 96.90
+	Hs
		557029 PGFRA_HUMAN (2-305): 8.6e-17: 87.9: 12.36		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Hs
		572583 VGFR1_HUMAN (3-112): 1.99e-14: 80.2: 13.01		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Hs
		580949 VGFR2_HUMAN (3-106): 1.62e-13: 77.5: 14.04		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Mm
		729715 VGFR1_MOUSE (3-112): 1.36e-14: 80.9: 13.82		PLCG1_MOUSE (1-1288): 0: 1302: 96.12
+	Mm
		729415 VGFR2_MOUSE (3-106): 2.04e-12: 73.6: 13.16		PLCG1_MOUSE (1-1288): 0: 1302: 96.12
+	Hs
		507835 FGFR1_HUMAN (4-235): 6.88e-22: 104: 13.25		PLCG2_HUMAN (18-1287): 0: 1128: 49.45
+	Mm
		452188 CSF1R_MOUSE (6-304): 6.2e-18: 91.3: 13.53		PLCG2_MOUSE (19-1287): 0: 1131: 50.12
+	Dm
		112240 M9MRE1_DROME (31-495): 6.65e-36: 149: 17.32		Q9VXH3_DROME (15-1215): 0: 945: 40.88
+	Hs
		499290 KIT_HUMAN (1-976): 0: 807: 100.00		PLCE1_HUMAN (157-454): 2.17e-75: 278: 35.69
+	Hs
		609614 FGFR3_HUMAN (3-331): 4.6e-51: 195: 13.39		PLCL2_HUMAN (840-1240): 4.61e-92: 324: 29.23