HitPredict

Interactor 1: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Interactor 2: SCF (P21583)
Kit ligand (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
Gene: KITLG

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.80 1.00 0.899

The method score is based on:

Property Details
Experiments 1379243, 1375232, 7680037, 17662946
Identification Methods pull down, affinity chromatography technology, x-ray crystallography, competition binding
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains SCF~ig
Common GO terms GO:0001541 - ovarian follicle development
GO:0002244 - hematopoietic progenitor cell differentiation
GO:0005615 - extracellular space
GO:0005886 - plasma membrane
GO:0008584 - male gonad development
and 5 others

more...
Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 976
Hs

1 273
+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024