HitPredict

Interactor 1: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Interactor 2: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.965

The method score is based on:

Property Details
Experiments 17452978, 12878163, 10022833, 11071635, 24728074, 7509796, 9233773, 1382595, 7537096
Identification Methods affinity chromatography technology, two hybrid, pull down, fluorescence polarization spectroscopy, coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~SH2
Common GO terms GO:0005886 - plasma membrane
GO:0005911 - cell-cell junction
GO:0019221 - cytokine-mediated signaling pathway
GO:0030183 - B cell differentiation
GO:0030217 - T cell differentiation
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 976
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024