HitPredict

Interactor 1: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Interactor 2: MATK (P42679)
Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (CSK homologous kinase) (CHK) (Hematopoietic consensus tyrosine-lacking kinase) (Protein kinase HYL) (Tyrosine-protein kinase CTK)
Gene: MATK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	7536744, 9038210
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0004713 - protein tyrosine kinase activity GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 507
+	Hs
		411962 KIT_HUMAN (1-976): 0: 807: 100.00		FYN_HUMAN (28-493): 0: 527: 32.23
+	Hs
		433226 KIT_HUMAN (1-976): 0: 807: 100.00		YES_HUMAN (4-493): 0: 523: 31.94
+	Hs
		499222 KIT_HUMAN (1-976): 0: 807: 100.00		SRC_HUMAN (30-493): 0: 523: 34.52
+	Hs
		454791 KIT_HUMAN (1-976): 0: 807: 100.00		FGR_HUMAN (4-494): 0: 519: 32.03
+	Hs
		411567 KIT_HUMAN (1-976): 0: 807: 100.00		LCK_HUMAN (39-492): 1.32e-180: 518: 34.62
+	Hs
		442765 KIT_HUMAN (1-976): 0: 807: 100.00		HCK_HUMAN (26-490): 3.62e-178: 512: 33.47
+	Mm
		403538 KIT_MOUSE (1-975): 0: 773: 79.63		MATK_MOUSE (1-507): 0: 544: 87.18
+	Hs
		337322 KIT_HUMAN (1-976): 0: 807: 100.00		ABL1_HUMAN (26-486): 1.44e-165: 499: 32.70
+	Hs
		499244 KIT_HUMAN (1-976): 0: 807: 100.00		ABL2_HUMAN (13-503): 2.01e-164: 498: 31.37
+	Hs
		433539 KIT_HUMAN (1-976): 0: 807: 100.00		LYN_HUMAN (14-490): 4.73e-171: 493: 31.73
+	Hs
		499249 KIT_HUMAN (1-976): 0: 807: 100.00		BLK_HUMAN (10-492): 2.69e-169: 489: 32.66
+	Hs
		499243 KIT_HUMAN (1-976): 0: 807: 100.00		TXK_HUMAN (1-484): 1.5e-154: 452: 29.47
+	Hs
		499242 KIT_HUMAN (1-976): 0: 807: 100.00		TEC_HUMAN (16-490): 3.23e-152: 450: 29.41
+	Mm
		404012 PGFRB_MOUSE (14-974): 0: 597: 29.51		FYN_MOUSE (28-493): 0: 526: 32.43
+	Hs
		411953 PGFRB_HUMAN (30-954): 0: 591: 30.62		FYN_HUMAN (28-493): 0: 527: 32.23
+	Hs
		433221 PGFRB_HUMAN (30-954): 0: 591: 30.62		YES_HUMAN (4-493): 0: 523: 31.94
+	Hs
		452338 PGFRB_HUMAN (30-954): 0: 591: 30.62		SRC_HUMAN (30-493): 0: 523: 34.52
+	Hs
		337317 PGFRB_HUMAN (30-954): 0: 591: 30.62		ABL1_HUMAN (26-486): 1.44e-165: 499: 32.70
+	Hs
		452370 PGFRB_HUMAN (30-954): 0: 591: 30.62		ABL2_HUMAN (13-503): 2.01e-164: 498: 31.37
+	Hs
		499266 KIT_HUMAN (1-976): 0: 807: 100.00		PTK6_HUMAN (66-479): 8.11e-80: 258: 38.73