HitPredict

Interactor 1: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Interactor 2: TEC (P42680)
Tyrosine-protein kinase Tec (EC 2.7.10.2)
Gene: TEC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.870

Property	Details
Experiments	11071635, 7526158, 24728074
Identification Methods	affinity chromatography technology, pull down, fluorescence polarization spectroscopy
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0035556 - intracellular signal transduction GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 631
+	Hs
		337322 KIT_HUMAN (1-976): 0: 807: 100.00		ABL1_HUMAN (143-624): 2.71e-169: 514: 37.30
+	Hs
		499244 KIT_HUMAN (1-976): 0: 807: 100.00		ABL2_HUMAN (124-631): 7.96e-168: 512: 36.59
+	Hs
		499249 KIT_HUMAN (1-976): 0: 807: 100.00		BLK_HUMAN (150-628): 1.68e-169: 494: 38.43
+	Hs
		499222 KIT_HUMAN (1-976): 0: 807: 100.00		SRC_HUMAN (127-627): 2.29e-166: 487: 35.24
+	Hs
		433226 KIT_HUMAN (1-976): 0: 807: 100.00		YES_HUMAN (111-627): 3.51e-163: 479: 34.08
+	Hs
		442765 KIT_HUMAN (1-976): 0: 807: 100.00		HCK_HUMAN (98-628): 1.96e-161: 474: 34.02
+	Hs
		411962 KIT_HUMAN (1-976): 0: 807: 100.00		FYN_HUMAN (165-627): 5.66e-161: 473: 36.83
+	Hs
		499243 KIT_HUMAN (1-976): 0: 807: 100.00		TXK_HUMAN (131-624): 1.99e-159: 469: 58.75
+	Hs
		411567 KIT_HUMAN (1-976): 0: 807: 100.00		LCK_HUMAN (151-627): 2.3e-158: 466: 35.34
+	Hs
		454791 KIT_HUMAN (1-976): 0: 807: 100.00		FGR_HUMAN (134-627): 1.14e-157: 465: 34.94
+	Hs
		433539 KIT_HUMAN (1-976): 0: 807: 100.00		LYN_HUMAN (145-627): 8.36e-153: 452: 34.68
+	Hs
		337317 PGFRB_HUMAN (30-954): 0: 591: 30.62		ABL1_HUMAN (143-624): 2.71e-169: 514: 37.30
+	Hs
		452370 PGFRB_HUMAN (30-954): 0: 591: 30.62		ABL2_HUMAN (124-631): 7.96e-168: 512: 36.59
+	Hs
		452338 PGFRB_HUMAN (30-954): 0: 591: 30.62		SRC_HUMAN (127-627): 2.29e-166: 487: 35.24
+	Mm
		404012 PGFRB_MOUSE (14-974): 0: 597: 29.51		FYN_MOUSE (165-627): 7.18e-161: 473: 36.83
+	Hs
		433221 PGFRB_HUMAN (30-954): 0: 591: 30.62		YES_HUMAN (111-627): 3.51e-163: 479: 34.08
+	Hs
		411953 PGFRB_HUMAN (30-954): 0: 591: 30.62		FYN_HUMAN (165-627): 5.66e-161: 473: 36.83
+	Hs
		337376 FLT3_HUMAN (11-968): 1.65e-171: 528: 29.98		ABL1_HUMAN (143-624): 2.71e-169: 514: 37.30
+	Hs
		412062 FLT3_HUMAN (11-968): 1.65e-171: 528: 29.98		FYN_HUMAN (165-627): 5.66e-161: 473: 36.83
+	Hs
		411619 FLT3_HUMAN (11-968): 1.65e-171: 528: 29.98		LCK_HUMAN (151-627): 2.3e-158: 466: 35.34