HitPredict

Interactor 1: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Interactor 2: KSYK (P43405)
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Gene: SYK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.47 1.00 0.692

The method score is based on:

Property Details
Experiments 24728074
Identification Methods pull down, fluorescence polarization spectroscopy
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms GO:0004713 - protein tyrosine kinase activity
GO:0005524 - ATP binding
GO:0005886 - plasma membrane
GO:0030183 - B cell differentiation
GO:0032765 - positive regulation of mast cell cytokine production
and 4 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 976
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024