HitPredict

Interactor 1: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.976

Property	Details
Experiments	10022833, 24728074, 17904548, 17452978, 7523859, 10377264, 8647802, 12444928, 8950973, 7523381
Identification Methods	two hybrid, pull down, affinity chromatography technology, unspecified method, coimmunoprecipitation, far western blotting, fluorescence polarization spectroscopy
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0007165 - signal transduction GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 217
+	Hs
		499264 KIT_HUMAN (1-976): 0: 807: 100.00		GRAP_HUMAN (1-213): 2.32e-66: 205: 56.74
+	Mm
		403541 KIT_MOUSE (1-975): 0: 773: 79.63		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Hs
		499291 KIT_HUMAN (1-976): 0: 807: 100.00		VAV3_HUMAN (1-212): 1.16e-43: 157: 22.00
+	Hs
		411567 KIT_HUMAN (1-976): 0: 807: 100.00		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		499266 KIT_HUMAN (1-976): 0: 807: 100.00		PTK6_HUMAN (4-141): 7.14e-23: 97.1: 38.93
+	Hs
		499225 KIT_HUMAN (1-976): 0: 807: 100.00		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		337322 KIT_HUMAN (1-976): 0: 807: 100.00		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		499244 KIT_HUMAN (1-976): 0: 807: 100.00		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Hs
		411962 KIT_HUMAN (1-976): 0: 807: 100.00		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433226 KIT_HUMAN (1-976): 0: 807: 100.00		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Hs
		454791 KIT_HUMAN (1-976): 0: 807: 100.00		FGR_HUMAN (120-215): 6.83e-13: 68.8: 22.45
+	Hs
		442765 KIT_HUMAN (1-976): 0: 807: 100.00		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Hs
		433539 KIT_HUMAN (1-976): 0: 807: 100.00		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		499222 KIT_HUMAN (1-976): 0: 807: 100.00		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		275165 KIT_HUMAN (1-976): 0: 807: 100.00		GRAP2_HUMAN (3-55): 1.58e-10: 61.3: 39.62
+	Mm
		403536 KIT_MOUSE (1-975): 0: 773: 79.63		VAV_MOUSE (2-60): 8.53e-15: 74.6: 42.37
+	Mm
		292679 KIT_MOUSE (1-975): 0: 773: 79.63		GRAP2_MOUSE (3-55): 1.57e-10: 61.5: 37.74
+	Mm
		404013 PGFRB_MOUSE (14-974): 0: 597: 29.51		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Hs
		337317 PGFRB_HUMAN (30-954): 0: 591: 30.62		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Mm
		404012 PGFRB_MOUSE (14-974): 0: 597: 29.51		FYN_MOUSE (161-215): 4.44e-14: 72.3: 31.58