HitPredict

Interactor 1: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Interactor 2: CBLB (Q13191)
E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)
Gene: CBLB

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	12177062
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 982
+	Hs
		499234 KIT_HUMAN (1-976): 0: 807: 100.00		CBL_HUMAN (25-976): 0: 675: 47.10
+	Hs
		452407 PGFRB_HUMAN (30-954): 0: 591: 30.62		CBLB_HUMAN (1-982): 0: 877: 100.00
+	Mm
		403532 KIT_MOUSE (1-975): 0: 773: 79.63		CBL_MOUSE (25-976): 0: 674: 47.47
+	Mm
		404008 PGFRB_MOUSE (14-974): 0: 597: 29.51		CBL_MOUSE (25-976): 0: 674: 47.47
+	Hs
		452353 PGFRB_HUMAN (30-954): 0: 591: 30.62		CBL_HUMAN (25-976): 0: 675: 47.10
+	Hs
		610268 FLT3_HUMAN (11-968): 1.65e-171: 528: 29.98		CBL_HUMAN (25-976): 0: 675: 47.10
+	Hs
		607956 FGFR4_HUMAN (4-224): 3.99e-23: 107: 13.21		CBLB_HUMAN (1-982): 0: 877: 100.00
+	Hs
		601457 FGFR2_HUMAN (8-323): 1.59e-55: 209: 13.10		CBL_HUMAN (25-976): 0: 675: 47.10
+	Dm
		112207 M9MRE1_DROME (31-495): 6.65e-36: 149: 17.32		O46034_DROME (27-434): 0: 718: 71.39
+	Hs
		607879 FGFR4_HUMAN (4-224): 3.99e-23: 107: 13.21		CBL_HUMAN (25-976): 0: 675: 47.10
+	Mm
		452178 CSF1R_MOUSE (6-304): 6.2e-18: 91.3: 13.53		CBL_MOUSE (25-976): 0: 674: 47.47
+	Hs
		557035 PGFRA_HUMAN (2-305): 8.6e-17: 87.9: 12.36		CBL_HUMAN (25-976): 0: 675: 47.10
+	Hs
		572586 VGFR1_HUMAN (3-112): 1.99e-14: 80.2: 13.01		CBL_HUMAN (25-976): 0: 675: 47.10
+	Mm
		610553 VGFR1_MOUSE (3-112): 1.36e-14: 80.9: 13.82		CBL_MOUSE (25-976): 0: 674: 47.47
+	Hs
		610266 VGFR2_HUMAN (3-106): 1.62e-13: 77.5: 14.04		CBL_HUMAN (25-976): 0: 675: 47.10
+	Rn
		88773 VGFR1_RAT (3-112): 2.34e-14: 80.2: 14.63		D3ZV15_RAT (25-931): 0: 647: 48.11
+	Hs
		608187 FGFR4_HUMAN (4-224): 3.99e-23: 107: 13.21		CBLC_HUMAN (29-497): 0: 585: 44.65
+	Hs
		508077 FGFR1_HUMAN (4-235): 6.88e-22: 104: 13.25		MICA3_HUMAN (397-980): 2.53e-15: 83.1: 12.89
+	Hs
		203204 FGFR1_HUMAN (4-235): 6.88e-22: 104: 13.25		SYNJ1_HUMAN (356-779): 6.17e-15: 82: 6.35
+	Rn
		94375 FGFR1_RAT (4-235): 6.64e-22: 104: 12.91		F1M9G7_RAT (411-858): 1.97e-09: 64.2: 9.91