HitPredict

Interactor 1: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Interactor 2: GRB10 (Q13322)
Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR)
Gene: GRB10

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.740

Property	Details
Experiments	11809791
Identification Methods	two hybrid, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	BPS~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 594
+	Hs
		499267 KIT_HUMAN (1-976): 0: 807: 100.00		GRB7_HUMAN (107-594): 1.36e-174: 507: 55.60
+	Mm
		403536 KIT_MOUSE (1-975): 0: 773: 79.63		VAV_MOUSE (36-592): 1.11e-137: 423: 14.55
+	Hs
		499291 KIT_HUMAN (1-976): 0: 807: 100.00		VAV3_HUMAN (37-592): 1.1e-99: 323: 12.20
+	Hs
		499242 KIT_HUMAN (1-976): 0: 807: 100.00		TEC_HUMAN (293-590): 2.81e-52: 191: 12.33
+	Hs
		411567 KIT_HUMAN (1-976): 0: 807: 100.00		LCK_HUMAN (420-589): 7.66e-49: 179: 19.66
+	Hs
		411962 KIT_HUMAN (1-976): 0: 807: 100.00		FYN_HUMAN (441-591): 5.64e-47: 174: 20.38
+	Hs
		433226 KIT_HUMAN (1-976): 0: 807: 100.00		YES_HUMAN (441-592): 9.17e-47: 174: 20.89
+	Hs
		499222 KIT_HUMAN (1-976): 0: 807: 100.00		SRC_HUMAN (443-590): 9.55e-47: 174: 22.08
+	Hs
		433539 KIT_HUMAN (1-976): 0: 807: 100.00		LYN_HUMAN (409-593): 7.45e-46: 171: 17.19
+	Hs
		442765 KIT_HUMAN (1-976): 0: 807: 100.00		HCK_HUMAN (406-593): 7.97e-46: 171: 18.78
+	Hs
		454791 KIT_HUMAN (1-976): 0: 807: 100.00		FGR_HUMAN (441-593): 8.45e-46: 171: 18.63
+	Hs
		499249 KIT_HUMAN (1-976): 0: 807: 100.00		BLK_HUMAN (449-593): 3.44e-45: 169: 22.82
+	Hs
		499241 KIT_HUMAN (1-976): 0: 807: 100.00		MATK_HUMAN (454-587): 1.29e-36: 144: 26.81
+	Mm
		403538 KIT_MOUSE (1-975): 0: 773: 79.63		MATK_MOUSE (454-587): 2.8e-40: 155: 28.26
+	Hs
		499264 KIT_HUMAN (1-976): 0: 807: 100.00		GRAP_HUMAN (489-575): 4.78e-25: 105: 32.18
+	Hs
		499253 KIT_HUMAN (1-976): 0: 807: 100.00		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		499246 KIT_HUMAN (1-976): 0: 807: 100.00		KSYK_HUMAN (459-593): 3.15e-16: 84.1: 27.94
+	Mm
		403541 KIT_MOUSE (1-975): 0: 773: 79.63		GRB2_MOUSE (489-575): 3.64e-20: 91.4: 29.89
+	Mm
		403542 KIT_MOUSE (1-975): 0: 773: 79.63		GRB10_MOUSE (57-148): 3.15e-14: 77.6: 69.15
+	Mm
		404012 PGFRB_MOUSE (14-974): 0: 597: 29.51		FYN_MOUSE (441-591): 5.64e-47: 174: 20.38