HitPredict

Interactor 1: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Interactor 2: GRB7 (Q14451)
Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein)
Gene: GRB7

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.849

Property	Details
Experiments	24728074, 10377264, 12444928
Identification Methods	pull down, unspecified method, fluorescence polarization spectroscopy
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	BPS~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0030335 - positive regulation of cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 532
+	Hs
		499263 KIT_HUMAN (1-976): 0: 807: 100.00		GRB10_HUMAN (1-532): 0: 593: 53.17
+	Mm
		403536 KIT_MOUSE (1-975): 0: 773: 79.63		VAV_MOUSE (85-526): 8.09e-90: 295: 15.52
+	Hs
		499291 KIT_HUMAN (1-976): 0: 807: 100.00		VAV3_HUMAN (81-526): 1.65e-62: 221: 10.44
+	Hs
		411567 KIT_HUMAN (1-976): 0: 807: 100.00		LCK_HUMAN (317-527): 2.74e-57: 200: 20.00
+	Hs
		499230 KIT_HUMAN (1-976): 0: 807: 100.00		PLCG1_HUMAN (200-532): 6.64e-50: 187: 14.69
+	Hs
		411962 KIT_HUMAN (1-976): 0: 807: 100.00		FYN_HUMAN (357-529): 5.57e-50: 182: 20.88
+	Hs
		433539 KIT_HUMAN (1-976): 0: 807: 100.00		LYN_HUMAN (347-531): 4.7e-49: 178: 18.46
+	Hs
		454791 KIT_HUMAN (1-976): 0: 807: 100.00		FGR_HUMAN (345-527): 5.44e-48: 176: 21.65
+	Hs
		433226 KIT_HUMAN (1-976): 0: 807: 100.00		YES_HUMAN (366-528): 8.94e-48: 175: 19.53
+	Hs
		499222 KIT_HUMAN (1-976): 0: 807: 100.00		SRC_HUMAN (351-528): 1.08e-46: 172: 24.32
+	Hs
		442765 KIT_HUMAN (1-976): 0: 807: 100.00		HCK_HUMAN (349-527): 4.62e-45: 168: 19.37
+	Hs
		499287 KIT_HUMAN (1-976): 0: 807: 100.00		SLAP2_HUMAN (355-528): 3.54e-42: 153: 19.55
+	Hs
		499241 KIT_HUMAN (1-976): 0: 807: 100.00		MATK_HUMAN (398-525): 4.78e-36: 142: 30.37
+	Mm
		403538 KIT_MOUSE (1-975): 0: 773: 79.63		MATK_MOUSE (398-525): 1.43e-39: 152: 30.37
+	Hs
		499246 KIT_HUMAN (1-976): 0: 807: 100.00		KSYK_HUMAN (412-531): 6.62e-17: 86: 30.00
+	Hs
		499264 KIT_HUMAN (1-976): 0: 807: 100.00		GRAP_HUMAN (395-513): 1.95e-14: 74.4: 25.21
+	Hs
		499253 KIT_HUMAN (1-976): 0: 807: 100.00		GRB2_HUMAN (427-513): 2.66e-13: 71: 29.89
+	Mm
		403542 KIT_MOUSE (1-975): 0: 773: 79.63		GRB10_MOUSE (2-77): 1.15e-12: 72.6: 33.33
+	Mm
		403541 KIT_MOUSE (1-975): 0: 773: 79.63		GRB2_MOUSE (427-513): 2.66e-13: 71: 29.89
+	Mm
		404012 PGFRB_MOUSE (14-974): 0: 597: 29.51		FYN_MOUSE (357-529): 5.57e-50: 182: 20.88