HitPredict

Interactor 1: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Interactor 2: SH2D3 (Q8N5H7)
SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1)
Gene: SH2D3C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.619

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 860
+	Hs
		275529 KIT_HUMAN (1-976): 0: 807: 100.00		BCAR3_HUMAN (55-860): 0: 715: 39.09
+	Hs
		411962 KIT_HUMAN (1-976): 0: 807: 100.00		FYN_HUMAN (82-423): 9e-64: 225: 10.99
+	Hs
		433226 KIT_HUMAN (1-976): 0: 807: 100.00		YES_HUMAN (81-393): 4.07e-61: 218: 11.78
+	Hs
		499222 KIT_HUMAN (1-976): 0: 807: 100.00		SRC_HUMAN (20-393): 2.03e-60: 216: 12.76
+	Hs
		454791 KIT_HUMAN (1-976): 0: 807: 100.00		FGR_HUMAN (112-393): 2.09e-58: 210: 14.29
+	Hs
		426940 KIT_HUMAN (1-976): 0: 807: 100.00		FES_HUMAN (1-394): 3.67e-54: 204: 18.75
+	Hs
		499249 KIT_HUMAN (1-976): 0: 807: 100.00		BLK_HUMAN (108-394): 1.28e-54: 199: 13.44
+	Hs
		433539 KIT_HUMAN (1-976): 0: 807: 100.00		LYN_HUMAN (132-424): 2.93e-54: 198: 11.39
+	Hs
		442765 KIT_HUMAN (1-976): 0: 807: 100.00		HCK_HUMAN (91-394): 1.07e-53: 197: 13.71
+	Hs
		411567 KIT_HUMAN (1-976): 0: 807: 100.00		LCK_HUMAN (123-424): 1.07e-53: 196: 10.59
+	Hs
		499274 KIT_HUMAN (1-976): 0: 807: 100.00		SHC4_HUMAN (8-321): 2.53e-52: 195: 18.67
+	Hs
		499247 KIT_HUMAN (1-976): 0: 807: 100.00		CRK_HUMAN (209-512): 9.59e-54: 190: 16.06
+	Hs
		499248 KIT_HUMAN (1-976): 0: 807: 100.00		CRKL_HUMAN (220-480): 2.1e-51: 184: 18.12
+	Hs
		499237 KIT_HUMAN (1-976): 0: 807: 100.00		SHC1_HUMAN (97-322): 5.53e-44: 170: 24.02
+	Hs
		499256 KIT_HUMAN (1-976): 0: 807: 100.00		SHC2_HUMAN (112-321): 2.18e-33: 138: 18.94
+	Hs
		499230 KIT_HUMAN (1-976): 0: 807: 100.00		PLCG1_HUMAN (105-427): 7.42e-27: 120: 14.37
+	Hs
		499253 KIT_HUMAN (1-976): 0: 807: 100.00		GRB2_HUMAN (214-310): 1.18e-27: 113: 27.00
+	Hs
		499264 KIT_HUMAN (1-976): 0: 807: 100.00		GRAP_HUMAN (215-385): 3.7e-26: 109: 21.02
+	Hs
		208982 KIT_HUMAN (1-976): 0: 807: 100.00		NCK2_HUMAN (98-309): 6.4e-23: 103: 18.72
+	Hs
		499235 KIT_HUMAN (1-976): 0: 807: 100.00		P85A_HUMAN (202-319): 6.33e-16: 84.3: 22.58