HitPredict

Interactor 1: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Interactor 2: SOCS4 (Q8WXH5)
Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7)
Gene: SOCS4

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17997974
Identification Methods	isothermal titration calorimetry
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 440
+	Hs
		256847 KIT_HUMAN (1-976): 0: 807: 100.00		SOCS5_HUMAN (7-436): 2.94e-135: 401: 52.72
+	Hs
		433226 KIT_HUMAN (1-976): 0: 807: 100.00		YES_HUMAN (151-429): 7.43e-47: 171: 14.19
+	Hs
		499222 KIT_HUMAN (1-976): 0: 807: 100.00		SRC_HUMAN (135-389): 2.54e-45: 166: 12.55
+	Hs
		146585 KIT_HUMAN (1-976): 0: 807: 100.00		SOCS2_HUMAN (234-425): 9.62e-47: 161: 25.85
+	Hs
		181778 KIT_HUMAN (1-976): 0: 807: 100.00		SOCS1_HUMAN (260-425): 6.95e-46: 159: 22.29
+	Hs
		411962 KIT_HUMAN (1-976): 0: 807: 100.00		FYN_HUMAN (202-387): 3.13e-42: 158: 17.10
+	Hs
		442765 KIT_HUMAN (1-976): 0: 807: 100.00		HCK_HUMAN (157-430): 3.66e-42: 158: 15.49
+	Hs
		454791 KIT_HUMAN (1-976): 0: 807: 100.00		FGR_HUMAN (186-433): 4.49e-42: 157: 16.92
+	Hs
		411567 KIT_HUMAN (1-976): 0: 807: 100.00		LCK_HUMAN (195-418): 6.26e-42: 156: 15.88
+	Hs
		147481 KIT_HUMAN (1-976): 0: 807: 100.00		SOCS6_HUMAN (239-424): 7.84e-40: 151: 32.00
+	Mm
		403545 KIT_MOUSE (1-975): 0: 773: 79.63		SOCS6_MOUSE (204-424): 1.31e-47: 173: 29.46
+	Hs
		147381 KIT_HUMAN (1-976): 0: 807: 100.00		SOCS3_HUMAN (250-422): 2.34e-37: 137: 20.09
+	Mm
		193336 KIT_MOUSE (1-975): 0: 773: 79.63		SOCS1_MOUSE (260-425): 1.6e-45: 158: 22.29
+	Hs
		499228 KIT_HUMAN (1-976): 0: 807: 100.00		PLCG2_HUMAN (258-399): 1.57e-23: 105: 18.88
+	Hs
		499230 KIT_HUMAN (1-976): 0: 807: 100.00		PLCG1_HUMAN (261-379): 1.1e-22: 103: 17.50
+	Hs
		129178 KIT_HUMAN (1-976): 0: 807: 100.00		P85B_HUMAN (231-382): 5.27e-18: 88.7: 20.65
+	Hs
		499280 KIT_HUMAN (1-976): 0: 807: 100.00		P55G_HUMAN (282-394): 1.03e-16: 84.1: 21.74
+	Hs
		499235 KIT_HUMAN (1-976): 0: 807: 100.00		P85A_HUMAN (225-392): 2.48e-15: 80.3: 18.71
+	Mm
		140055 KIT_MOUSE (1-975): 0: 773: 79.63		P85B_MOUSE (225-389): 1.22e-20: 96.5: 18.61
+	Mm
		403533 KIT_MOUSE (1-975): 0: 773: 79.63		P85A_MOUSE (225-392): 2.99e-15: 79.9: 18.71