HitPredict

Interactor 1: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Interactor 2: SHC3 (Q92529)
SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3)
Gene: SHC3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 594
+	Hs
		499237 KIT_HUMAN (1-976): 0: 807: 100.00		SHC1_HUMAN (3-593): 5.76e-176: 512: 46.65
+	Hs
		499274 KIT_HUMAN (1-976): 0: 807: 100.00		SHC4_HUMAN (1-593): 1.37e-158: 469: 43.61
+	Hs
		499256 KIT_HUMAN (1-976): 0: 807: 100.00		SHC2_HUMAN (47-593): 4.99e-147: 438: 43.96
+	Hs
		275529 KIT_HUMAN (1-976): 0: 807: 100.00		BCAR3_HUMAN (342-592): 6.06e-51: 190: 21.13
+	Hs
		499222 KIT_HUMAN (1-976): 0: 807: 100.00		SRC_HUMAN (361-594): 3.73e-49: 181: 18.18
+	Hs
		433226 KIT_HUMAN (1-976): 0: 807: 100.00		YES_HUMAN (355-594): 1.37e-48: 179: 17.31
+	Hs
		442765 KIT_HUMAN (1-976): 0: 807: 100.00		HCK_HUMAN (360-594): 1.32e-47: 176: 15.54
+	Hs
		454791 KIT_HUMAN (1-976): 0: 807: 100.00		FGR_HUMAN (359-594): 1.87e-47: 175: 18.22
+	Hs
		499244 KIT_HUMAN (1-976): 0: 807: 100.00		ABL2_HUMAN (342-592): 8.81e-45: 173: 15.91
+	Hs
		411962 KIT_HUMAN (1-976): 0: 807: 100.00		FYN_HUMAN (438-585): 3.12e-44: 167: 20.76
+	Hs
		433539 KIT_HUMAN (1-976): 0: 807: 100.00		LYN_HUMAN (404-594): 8.1e-44: 165: 20.69
+	Hs
		499269 KIT_HUMAN (1-976): 0: 807: 100.00		SHB_HUMAN (363-590): 9.97e-43: 162: 22.36
+	Hs
		499275 KIT_HUMAN (1-976): 0: 807: 100.00		SH2D3_HUMAN (371-592): 3.62e-41: 161: 19.16
+	Hs
		426940 KIT_HUMAN (1-976): 0: 807: 100.00		FES_HUMAN (431-594): 4.92e-36: 146: 22.56
+	Mm
		403544 KIT_MOUSE (1-975): 0: 773: 79.63		SH2B1_MOUSE (302-594): 6.65e-44: 169: 20.38
+	Hs
		499253 KIT_HUMAN (1-976): 0: 807: 100.00		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Mm
		403530 KIT_MOUSE (1-975): 0: 773: 79.63		FES_MOUSE (424-594): 9.91e-37: 148: 22.81
+	Mm
		403541 KIT_MOUSE (1-975): 0: 773: 79.63		GRB2_MOUSE (445-594): 3.77e-35: 133: 22.08
+	Hs
		499225 KIT_HUMAN (1-976): 0: 807: 100.00		NCK1_HUMAN (478-586): 2.54e-13: 73.7: 24.56
+	Mm
		404012 PGFRB_MOUSE (14-974): 0: 597: 29.51		FYN_MOUSE (438-585): 3.12e-44: 167: 20.76