HitPredict

Interactor 1: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Interactor 2: P55G (Q92569)
Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK)
Gene: PIK3R3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0030183 - B cell differentiation GO:0030217 - T cell differentiation GO:0030335 - positive regulation of cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 461
+	Hs
		337322 KIT_HUMAN (1-976): 0: 807: 100.00		ABL1_HUMAN (3-461): 1.02e-93: 308: 16.12
+	Hs
		499235 KIT_HUMAN (1-976): 0: 807: 100.00		P85A_HUMAN (48-455): 9.1e-92: 295: 79.17
+	Hs
		129178 KIT_HUMAN (1-976): 0: 807: 100.00		P85B_HUMAN (56-453): 2.19e-87: 283: 74.12
+	Hs
		146585 KIT_HUMAN (1-976): 0: 807: 100.00		SOCS2_HUMAN (40-144): 7.17e-30: 117: 28.95
+	Hs
		499244 KIT_HUMAN (1-976): 0: 807: 100.00		ABL2_HUMAN (324-459): 5.26e-21: 98.5: 25.36
+	Hs
		411567 KIT_HUMAN (1-976): 0: 807: 100.00		LCK_HUMAN (309-458): 5.54e-21: 97.3: 25.95
+	Hs
		411962 KIT_HUMAN (1-976): 0: 807: 100.00		FYN_HUMAN (326-459): 6.82e-20: 94.2: 26.06
+	Hs
		442765 KIT_HUMAN (1-976): 0: 807: 100.00		HCK_HUMAN (310-458): 1.43e-19: 93.1: 26.75
+	Hs
		433226 KIT_HUMAN (1-976): 0: 807: 100.00		YES_HUMAN (317-459): 6.84e-19: 91.2: 23.72
+	Hs
		499222 KIT_HUMAN (1-976): 0: 807: 100.00		SRC_HUMAN (323-459): 8.26e-19: 90.8: 24.14
+	Hs
		454791 KIT_HUMAN (1-976): 0: 807: 100.00		FGR_HUMAN (323-459): 2.54e-18: 89.2: 26.21
+	Hs
		499249 KIT_HUMAN (1-976): 0: 807: 100.00		BLK_HUMAN (285-458): 2.65e-18: 89.2: 23.50
+	Hs
		433539 KIT_HUMAN (1-976): 0: 807: 100.00		LYN_HUMAN (298-458): 6.17e-18: 88.1: 24.85
+	Hs
		147481 KIT_HUMAN (1-976): 0: 807: 100.00		SOCS6_HUMAN (47-165): 1.85e-17: 86.8: 31.06
+	Hs
		499291 KIT_HUMAN (1-976): 0: 807: 100.00		VAV3_HUMAN (44-159): 6.81e-16: 82.5: 30.17
+	Hs
		499256 KIT_HUMAN (1-976): 0: 807: 100.00		SHC2_HUMAN (39-162): 7.97e-14: 75.6: 30.65
+	Hs
		499241 KIT_HUMAN (1-976): 0: 807: 100.00		MATK_HUMAN (341-456): 1.11e-12: 71.8: 22.22
+	Hs
		499279 KIT_HUMAN (1-976): 0: 807: 100.00		SHC3_HUMAN (43-164): 3.62e-12: 70.2: 31.15
+	Hs
		181778 KIT_HUMAN (1-976): 0: 807: 100.00		SOCS1_HUMAN (46-169): 5.58e-13: 69.8: 23.20
+	Hs
		499228 KIT_HUMAN (1-976): 0: 807: 100.00		PLCG2_HUMAN (337-452): 6.98e-12: 69.8: 33.33