HitPredict

Interactor 1: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Interactor 2: SHIP1 (Q92835)
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN)
Gene: INPP5D

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	11071635
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0035556 - intracellular signal transduction
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 976 Hs			1 1189
+	Hs
		738250 FLT3_HUMAN (11-968): 1.65e-171: 528: 29.98		SHIP1_HUMAN (1-1189): 0: 883: 100.00
+	Hs
		243125 KIT_HUMAN (1-976): 0: 807: 100.00		SH21A_HUMAN (7-101): 2.92e-20: 89.7: 45.26
+	Hs
		601498 FGFR2_HUMAN (8-323): 1.59e-55: 209: 13.10		OCRL_HUMAN (269-781): 8.78e-142: 453: 23.43
+	Hs
		607945 FGFR4_HUMAN (4-224): 3.99e-23: 107: 13.21		OCRL_HUMAN (269-781): 8.78e-142: 453: 23.43
+	Hs
		507956 FGFR1_HUMAN (4-235): 6.88e-22: 104: 13.25		OCRL_HUMAN (269-781): 8.78e-142: 453: 23.43
+	Hs
		557095 PGFRA_HUMAN (2-305): 8.6e-17: 87.9: 12.36		OCRL_HUMAN (269-781): 8.78e-142: 453: 23.43
+	Hs
		203204 FGFR1_HUMAN (4-235): 6.88e-22: 104: 13.25		SYNJ1_HUMAN (720-1118): 4.38e-12: 73.1: 10.05