HitPredict

Interactor 1: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12177062
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0008360 - regulation of cell shape
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 665
+	Hs
		452467 PGFRB_HUMAN (30-954): 0: 591: 30.62		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		499225 KIT_HUMAN (1-976): 0: 807: 100.00		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		499253 KIT_HUMAN (1-976): 0: 807: 100.00		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Mm
		403541 KIT_MOUSE (1-975): 0: 773: 79.63		GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91
+	Hs
		275165 KIT_HUMAN (1-976): 0: 807: 100.00		GRAP2_HUMAN (1-56): 2.18e-17: 85.8: 32.14
+	Hs
		208982 KIT_HUMAN (1-976): 0: 807: 100.00		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77
+	Mm
		292679 KIT_MOUSE (1-975): 0: 773: 79.63		GRAP2_MOUSE (1-55): 2.15e-16: 82.8: 30.91
+	Mm
		403536 KIT_MOUSE (1-975): 0: 773: 79.63		VAV_MOUSE (84-158): 6.98e-13: 74: 27.63
+	Mm
		404013 PGFRB_MOUSE (14-974): 0: 597: 29.51		GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91
+	Hs
		452344 PGFRB_HUMAN (30-954): 0: 591: 30.62		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		452385 PGFRB_HUMAN (30-954): 0: 591: 30.62		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		208979 PGFRB_HUMAN (30-954): 0: 591: 30.62		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77
+	Hs
		452342 PGFRB_HUMAN (30-954): 0: 591: 30.62		VAV_HUMAN (84-158): 4.66e-13: 74.7: 28.95
+	Hs
		738192 FLT3_HUMAN (11-968): 1.65e-171: 528: 29.98		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		601492 FGFR2_HUMAN (8-323): 1.59e-55: 209: 13.10		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		601605 FGFR2_HUMAN (8-323): 1.59e-55: 209: 13.10		ITSN2_HUMAN (30-455): 2.08e-26: 117: 15.30
+	Hs
		609244 FGFR3_HUMAN (3-331): 4.6e-51: 195: 13.39		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		557606 FGFR4_HUMAN (4-224): 3.99e-23: 107: 13.21		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Dm
		112243 M9MRE1_DROME (31-495): 6.65e-36: 149: 17.32		CRK_DROME (3-162): 1.74e-11: 67: 29.76
+	Hs
		208993 FGFR4_HUMAN (4-224): 3.99e-23: 107: 13.21		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77